Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

Goran Bjelakovic; Dimitrinka Nikolova; Christian Gluud

doi:10.1371/journal.pone.0074558

Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

Goran Bjelakovic, Dimitrinka Nikolova, Christian Gluud

Copenhagen Trial Unit

150 Citations (Scopus)

Abstract

Evidence shows that antioxidant supplements may increase mortality. Our aims were to assess whether different doses of beta-carotene, vitamin A, and vitamin E affect mortality in primary and secondary prevention randomized clinical trials with low risk of bias.

Original language	English
Journal	P L o S One
Volume	8
Issue number	9
Pages (from-to)	e74558
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0074558
Publication status	Published - 2013

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Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? / Bjelakovic, Goran; Nikolova, Dimitrinka ; Gluud, Christian.
In: P L o S One, Vol. 8, No. 9, 2013, p. e74558.

Research output: Contribution to journal › Journal article › Research › peer-review

Bjelakovic, G, Nikolova, D & Gluud, C 2013, 'Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?', P L o S One, vol. 8, no. 9, pp. e74558. https://doi.org/10.1371/journal.pone.0074558

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Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

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