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Rigshospitalet - a part of Copenhagen University Hospital
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Whole-body MRI assessment of disease activity and structural damage in rheumatoid arthritis: first step towards an MRI joint count

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  1. Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis

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  2. Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis

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  3. Secular trends in the incidence and prevalence of gout in Denmark from 1995 to 2015: a nationwide register-based study

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  1. How do people with rheumatoid arthritis experience participation in a smoking cessation trial: a qualitative study

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  2. Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort

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Objective. The aim of this study was to investigate the ability of whole-body MRI (WBMRI) to visualize inflammation [synovitis, bone marrow oedema (BME) and enthesitis] and structural damage in patients with RA.Methods. The 3T WBMR images were acquired in a head-to-toe scan in 20 patients with RA and at least one swollen or tender joint. Short Tau Inversion Recovery and pre- and post-contrast T1-weighted images were evaluated for readability and the presence/absence of inflammation (synovitis, BME and enthesitis) and structural damage (erosions and fat infiltrations) in 76 peripheral joints, 30 entheseal sites and in the spine.Results. The readability was >70% for all individual joints, except for the most peripheral joints of the hands and feet. Synovitis was most frequent in the wrist, first tarsometatarsal, first CMC joints and glenohumeral joints (67-61%); BME in the wrist, CMC, acromioclavicular and glenohumeral joints (45-35%) and erosions in the wrist, MTP and CMC joints (19-16%). Enthesitis at ≥1 site was registered in 16 patients. BME was frequently seen in the cervical (20%) but not the thoracic and lumbar spine, while fat infiltrations and erosions were rare. The intrareader agreement was high (85-100%) for all pathologies. The agreement between WBMRI and clinical findings was low.Conclusion. Peripheral and axial inflammation and structural damage at joints and entheses was frequently identified by WBMRI, and more frequently than by clinical examination. WBMRI is a promising tool for evaluation of the total inflammatory load of inflammation (an MRI joint count) and structural damage in RA patients.
Original languageEnglish
JournalRheumatology (Oxford, England)
Volume53
Issue number5
Pages (from-to)845-53
Number of pages9
ISSN1462-0324
DOIs
Publication statusPublished - 3 Jan 2014

ID: 42481311