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Rigshospitalet - a part of Copenhagen University Hospital
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Usefulness of Soluble Urokinase Plasminogen Activator Receptor to Predict Repeat Myocardial Infarction and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention

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  1. Coronary risk of patients with valvular heart disease: prospective validation of CT-Valve Score

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  2. Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery

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  3. Left-sided heart disease and risk of death in patients with end-stage kidney disease receiving haemodialysis: an observational study

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The plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is an independent predictor of cardiovascular disease and all-cause mortality in healthy subjects. The prognostic capability of suPAR, its temporal course, and its relation to plasma C-reactive protein (CRP) in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous intervention (PCI) is unknown. Therefore, the plasma suPAR and CRP levels were measured in 296 consecutive patients with ST-segment elevation myocardial infarction admitted for primary PCI at baseline and every 6 to 8 hours thereafter until the cardiac biomarker levels had peaked. The end points were all-cause mortality and fatal or nonfatal recurrent myocardial infarction (MI). During a median follow-up period of 5.75 years, 69 deaths and 48 nonfatal and 14 fatal recurrent MIs occurred. All-cause mortality increased significantly from 8.1% to 41.5% across increasing quartiles of suPAR levels at the end of follow-up (log-rank p
Original languageEnglish
JournalAmerican Journal of Cardiology
Volume110
Issue number12
Pages (from-to)1756-63
Number of pages8
ISSN0002-9149
DOIs
Publication statusPublished - 2012

ID: 36609982