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Rigshospitalet - a part of Copenhagen University Hospital
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Unravelling the nuclear matrix proteome

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The nuclear matrix (NM) model posits the presence of a protein/RNA scaffold that spans the mammalian nucleus. The NM proteins are involved in basic nuclear function and are a promising source of protein biomarkers for cancer. Importantly, the NM proteome is operationally defined as the proteins from cells and tissue that are extracted following a specific biochemical protocol; in brief, the soluble proteins and lipids, cytoskeleton, and chromatin elements are removed in a sequential fashion, leaving behind the proteins that compose the NM. So far, the NM has not been sufficiently verified as a biological entity and only preliminary at the molecular level. Here, we argue for a combined effort of proteomics, immunodetection and microscopy to unravel the composition and structure of the NM.

Original languageEnglish
JournalJournal of Proteomics
Volume72
Issue number1
Pages (from-to)71-81
Number of pages11
ISSN1874-3919
DOIs
Publication statusPublished - 15 Feb 2009

    Research areas

  • Animals, Humans, Microscopy, Electron, Transmission, Neoplasms, Nuclear Matrix, Nuclear Matrix-Associated Proteins, Proteome, Journal Article, Review

ID: 49497079