Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis: a prospective cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, AW, Rifbjerg-Madsen, S, Christensen, R, Dreyer, L, Boesen, M, Ellegaard, K, Bliddal, H & Danneskiold-Samsøe, B 2016, 'Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis: a prospective cohort study', Rheumatology, vol. 55, no. 6, pp. 1091-8. https://doi.org/10.1093/rheumatology/kew034

APA

Christensen, A. W., Rifbjerg-Madsen, S., Christensen, R., Dreyer, L., Boesen, M., Ellegaard, K., Bliddal, H., & Danneskiold-Samsøe, B. (2016). Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis: a prospective cohort study. Rheumatology, 55(6), 1091-8. https://doi.org/10.1093/rheumatology/kew034

CBE

MLA

Vancouver

Author

Christensen, Anton W ; Rifbjerg-Madsen, Signe ; Christensen, Robin ; Dreyer, Lene ; Boesen, Mikael ; Ellegaard, Karen ; Bliddal, Henning ; Danneskiold-Samsøe, Bente. / Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis : a prospective cohort study. In: Rheumatology. 2016 ; Vol. 55, No. 6. pp. 1091-8.

Bibtex

@article{6bfa16972da6423a8f59083f44708acd,
title = "Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis: a prospective cohort study",
abstract = "OBJECTIVE: Previous studies have suggested a link between inflammation and central sensitization of pain in patients with RA. We conducted a prospective cohort study to determine whether US Doppler (USD), temporal summation (TS) of pain-assessed at baseline-and the potential interaction between them could predict the treatment response in RA.METHODS: Patients were recruited from Departments of Rheumatology in the Copenhagen area and from private clinics. RA patients, who were scheduled to initiate therapy with either a conventional synthetic DMARD (csDMARD; including DMARD-na{\"i}ve patients) or a biologic DMARD (bDMARD) agent (including bDMARD switch), were included and examined before the start of treatment and after 4 months. During the 4 months, patients received routine care from their treating rheumatologist.RESULTS: Multiple regression analysis was conducted, with change in DAS28 as the dependent variable. In unadjusted models, baseline USD score was significantly associated with DAS28 (β = 0.06; 95% CI: 0.02, 0.09; P < 0.001), whereas TS and their interaction were not. After adjusting for age, sex, disease duration, baseline DAS28 and whether patients initiated a csDMARD or a bDMARD, the USD score was still significantly associated with change in DAS28 (β = 0.032; 95% CI: 0.001, 0.064; P = 0.046), whereas TS remained insignificant.CONCLUSION: USD assessed at baseline is valuable as a prognostic factor for change in disease activity in 'real-life' RA patients. We did not find evidence to suggest that TS or the interaction between USD and TS was prognostically important for this group of patients.",
keywords = "Journal Article",
author = "Christensen, {Anton W} and Signe Rifbjerg-Madsen and Robin Christensen and Lene Dreyer and Mikael Boesen and Karen Ellegaard and Henning Bliddal and Bente Danneskiold-Sams{\o}e",
note = "{\textcopyright} The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
year = "2016",
month = jun,
doi = "10.1093/rheumatology/kew034",
language = "English",
volume = "55",
pages = "1091--8",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Ultrasound Doppler but not temporal summation of pain predicts DAS28 response in rheumatoid arthritis

T2 - a prospective cohort study

AU - Christensen, Anton W

AU - Rifbjerg-Madsen, Signe

AU - Christensen, Robin

AU - Dreyer, Lene

AU - Boesen, Mikael

AU - Ellegaard, Karen

AU - Bliddal, Henning

AU - Danneskiold-Samsøe, Bente

N1 - © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PY - 2016/6

Y1 - 2016/6

N2 - OBJECTIVE: Previous studies have suggested a link between inflammation and central sensitization of pain in patients with RA. We conducted a prospective cohort study to determine whether US Doppler (USD), temporal summation (TS) of pain-assessed at baseline-and the potential interaction between them could predict the treatment response in RA.METHODS: Patients were recruited from Departments of Rheumatology in the Copenhagen area and from private clinics. RA patients, who were scheduled to initiate therapy with either a conventional synthetic DMARD (csDMARD; including DMARD-naïve patients) or a biologic DMARD (bDMARD) agent (including bDMARD switch), were included and examined before the start of treatment and after 4 months. During the 4 months, patients received routine care from their treating rheumatologist.RESULTS: Multiple regression analysis was conducted, with change in DAS28 as the dependent variable. In unadjusted models, baseline USD score was significantly associated with DAS28 (β = 0.06; 95% CI: 0.02, 0.09; P < 0.001), whereas TS and their interaction were not. After adjusting for age, sex, disease duration, baseline DAS28 and whether patients initiated a csDMARD or a bDMARD, the USD score was still significantly associated with change in DAS28 (β = 0.032; 95% CI: 0.001, 0.064; P = 0.046), whereas TS remained insignificant.CONCLUSION: USD assessed at baseline is valuable as a prognostic factor for change in disease activity in 'real-life' RA patients. We did not find evidence to suggest that TS or the interaction between USD and TS was prognostically important for this group of patients.

AB - OBJECTIVE: Previous studies have suggested a link between inflammation and central sensitization of pain in patients with RA. We conducted a prospective cohort study to determine whether US Doppler (USD), temporal summation (TS) of pain-assessed at baseline-and the potential interaction between them could predict the treatment response in RA.METHODS: Patients were recruited from Departments of Rheumatology in the Copenhagen area and from private clinics. RA patients, who were scheduled to initiate therapy with either a conventional synthetic DMARD (csDMARD; including DMARD-naïve patients) or a biologic DMARD (bDMARD) agent (including bDMARD switch), were included and examined before the start of treatment and after 4 months. During the 4 months, patients received routine care from their treating rheumatologist.RESULTS: Multiple regression analysis was conducted, with change in DAS28 as the dependent variable. In unadjusted models, baseline USD score was significantly associated with DAS28 (β = 0.06; 95% CI: 0.02, 0.09; P < 0.001), whereas TS and their interaction were not. After adjusting for age, sex, disease duration, baseline DAS28 and whether patients initiated a csDMARD or a bDMARD, the USD score was still significantly associated with change in DAS28 (β = 0.032; 95% CI: 0.001, 0.064; P = 0.046), whereas TS remained insignificant.CONCLUSION: USD assessed at baseline is valuable as a prognostic factor for change in disease activity in 'real-life' RA patients. We did not find evidence to suggest that TS or the interaction between USD and TS was prognostically important for this group of patients.

KW - Journal Article

U2 - 10.1093/rheumatology/kew034

DO - 10.1093/rheumatology/kew034

M3 - Journal article

C2 - 26983452

VL - 55

SP - 1091

EP - 1098

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 6

ER -

ID: 48268791