Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Response to letter of concern regarding »Reduction in COVID-19 infection using surgical facial masks outside the healthcare system«

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multivitamin intake does not affect the risk of preterm and very preterm birth

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Time from injury to arrival at the trauma centre in patients undergoing interhospital transfer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Nusinersen treatment of spinal muscular atrophy - a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term employment, education, and healthcare costs of childhood and adolescent onset of epilepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Severe hypersomnia after unilateral infarction in the pulvinar nucleus- a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Large genome-wide association study identifies three novel risk variants for restless legs syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A review of sleep research in patients with spinal cord injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Characterization of Blood Pressure and Heart Rate Oscillations in POTS Patients via Uniform Phase Empirical Mode Decomposition

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.

METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.

RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.

CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

Original languageEnglish
JournalDanish Medical Journal
Volume65
Issue number11
Pages (from-to)A6511
ISSN1603-9629
Publication statusPublished - Nov 2018

ID: 55616987