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Rigshospitalet - a part of Copenhagen University Hospital
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Treatment of micro air bubbles in rat adipose tissue at 25 kPa altitude exposures with perfluorocarbon emulsions and nitric oxide

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  2. Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders

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  3. Blood pooling in extrathoracic veins after glossopharyngeal insufflation

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  1. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen

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  2. Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

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  3. Eubs president's message

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Perfluorocarbon emulsions (PFC) and nitric oxide (NO) releasing agents have on experimental basis demonstrated therapeutic properties in treating and preventing the formation of venous gas embolism as well as increased survival rate during decompression sickness from diving. The effect is ascribed to an increased solubility and transport capacity of respiratory gases in the PFC emulsion and possibly enhanced nitrogen washout through NO-increased blood flow rate and/or the removal of endothelial micro bubble nuclei precursors. Previous reports have shown that metabolic gases (i.e., oxygen in particular) and water vapor contribute to bubble growth and stabilization during altitude exposures. Accordingly, we hypothesize that the administration of PFC and NO donors upon hypobaric pressure exposures either (1) enhance the bubble disappearance rate through faster desaturation of nitrogen, or in contrast (2) promote bubble growth and stabilization through an increased oxygen supply.
Original languageEnglish
JournalEuropean Journal of Applied Physiology
Volume114
Issue number1
Pages (from-to)135-46
ISSN1439-6319
DOIs
Publication statusPublished - 2014

ID: 41960978