Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Treating Hypothyroidism with Thyroxine/Triiodothyronine Combination Therapy in Denmark: Following Guidelines or Following Trends?

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Risk of Thyroid Cancer in 1,504 Patients Referred for Thyroid Surgery with Assumed Benign Histology

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Trends in Costs of Thyroid Disease Treatment in Denmark during 1995-2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High Level of Agreement between Electronic and Paper Mode of Administration of a Thyroid-Specific Patient-Reported Outcome, ThyPRO

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Radioiodine Therapy Does Not Change the Atherosclerotic Burden of the Carotid Arteries

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Radiation Induced Atherosclerosis – A Possible Side Effect of Radioiodine Therapy

    Research output: Book/ReportPh.D. thesisResearch

  3. Radioiodine therapy increases the risk of cerebrovascular events in hyperthyroid and euthyroid patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Modeling the absorbed dose to the common carotid arteries following radioiodine treatment of benign thyroid disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Luba Freja Michaelsson
  • Bjarke Borregaard Medici
  • Jeppe Lerche la Cour
  • Christian Selmer
  • Michael Røder
  • Hans Perrild
  • Nils Knudsen
  • Jens Faber
  • Birte Nygaard
View graph of relations

BACKGROUND: Five to ten percent of patients with hypothyroidism describe persistent symptoms despite being biochemically well regulated on levothyroxine (L-T4). Thyroxine (T4)/triiodothyronine (T3) combination therapy [L-T4/liothyronine (L-T3) or desiccated thyroid] are still regarded as experimental with no evidence of superior effect on persistent symptoms according to meta-analyses. However, some randomized controlled trials have demonstrated patients' preference for T4/T3 combination therapy as compared to L-T4 monotherapy. In 2013, attention to combination therapy increased in Denmark after a patient published a book describing her experiences with hypothyroidism and treatment.

OBJECTIVE: To investigate current Danish trends in the use of T4/T3 combination therapy.

METHODS: We used an Internet-based questionnaire, distributed as a link via two Danish patient fora. Further, information was obtained from the Division of Pharmacies and Reimbursement at the Danish Health and Medicines Authority and from the only pharmacy in Denmark producing desiccated thyroid and L-T3 tablets.

RESULTS: A total of 384 patients answered the questionnaire, and 293 responders were included. Sixty-nine percent of the responders had six or more symptoms, and 84% reported a treatment effect. Forty-four percent of the responders received their prescriptions from general practitioners; 50% received desiccated thyroid and 28% reported that they adjust their dose themselves. Responders followed by general practitioners more frequently received desiccated thyroid and adjusted their dose themselves.

CONCLUSIONS: Increased media focus has changed the prescription pattern of thyroid hormones; European guidelines on T4/T3 combination therapy are not always followed in Denmark and many patients adjust their medication themselves and may therefore be at risk of overtreatment.

Original languageEnglish
JournalEuropean Thyroid Journal
Volume4
Issue number3
Pages (from-to)174-80
Number of pages7
ISSN2235-0640
DOIs
Publication statusPublished - Sep 2015

ID: 46003041