Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Transplantation of adult monkey neural stem cells into a contusion spinal cord injury model in rhesus macaque monkeys

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients With ST-Segment-Elevation Myocardial Infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sibling history is associated with heart failure after a first myocardial infarction

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Subsequent Event Risk in Individuals With Established Coronary Heart Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Shiva Nemati Nemati
  • Reza Jabbari
  • Mostafa Hajinasrollah
  • Nargess Zare Mehrjerdi
  • Hossein Azizi
  • Katayoun Hemmesi
  • Reza Moghiminasr
  • Zahra Azhdari
  • Ardeshir Talebi
  • Soroush Mohitmafi
  • Ahmad Vosough Taqi Dizaj
  • Giuve Sharifi
  • Hossein Baharvand
  • Omidvar Rezaee
  • Sahar Kiani
View graph of relations

OBJECTIVE: Currently, cellular transplantation for spinal cord injuries (SCI) is the subject of numerous preclinical studies. Among the many cell types in the adult brain, there is a unique subpopulation of neural stem cells (NSC) that can self-renew and differentiate into neurons. The study aims, therefore, to explore the efficacy of adult monkey NSC (mNSC) in a primate SCI model.

MATERIALS AND METHODS: In this experimental study, isolated mNSCs were analyzed by flow cytometry, immunocytochemistry, and RT-PCR. Next, BrdU-labeled cells were transplanted into a SCI model. The SCI animal model was confirmed by magnetic resonance imaging (MRI) and histological analysis. Animals were clinically observed for 6 months.

RESULTS: Analysis confirmed homing of mNSCs into the injury site. Transplanted cells expressed neuronal markers (TubIII). Hind limb performance improved in trans- planted animals based on Tarlov's scale and our established behavioral tests for monkeys.

CONCLUSION: Our findings have indicated that mNSCs can facilitate recovery in contusion SCI models in rhesus macaque monkeys. Additional studies are necessary to determine the im- provement mechanisms after cell transplantation.

Original languageEnglish
JournalCell Journal
Volume16
Issue number2
Pages (from-to)117-30
Number of pages14
ISSN2228-5806
Publication statusPublished - 2014

ID: 45069344