Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital

Tobacco use in the Myeloproliferative neoplasms: symptom burden, patient opinions, and care

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Decreased plasma lipid levels in a statin-free Danish primary health care cohort between 2001 and 2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Risk of over- And under- treatment with levothyroxine in primary care in Copenhagen, Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sarah F Christensen
  • Robyn M Scherber
  • Gina L Mazza
  • Amylou C Dueck
  • Nana Brochmann
  • Christen L Andersen
  • Hans C Hasselbalch
  • Ruben A Mesa
  • Holly L Geyer
View graph of relations

BACKGROUND: Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancies. The aim of this study was to analyze the association between smoking and MPN-related symptom burden and explore MPN patients' opinions on smoking.

METHODS: A total of 435 patients with MPN participated in a cross-sectional internet-based survey developed by the Mayo Clinic and the Myeloproliferative Neoplasm Quality of Life Group. Patients reported their demographics, disease characteristics, tobacco use, and opinions on tobacco use. In addition, MPN-related symptoms were reported via the validated 10-item version of the Myeloproliferative Neoplasms Symptom Assessment Form.

RESULTS: Current/former smokers reported worse fatigue (mean severity 5.6 vs. 5.0, p = 0.02) and inactivity (mean severity 4.0 vs. 3.4, p = 0.03) than never smokers. Moreover, current/former smokers more frequently experienced early satiety (68.5% vs. 58.3%, p = 0.03), inactivity (79.9% vs. 71.1%, p = 0.04), and concentration difficulties (82.1% vs. 73.1%, p = 0.04). Although not significant, a higher total symptom burden was observed for current/former smokers (mean 30.4 vs. 27.0, p = 0.07). Accordingly, overall quality of life was significantly better among never smokers than current/former smokers (mean 3.5 vs. 3.9, p = 0.03). Only 43.2% of the current/former smokers reported having discussed tobacco use with their physician, and 17.5% did not believe smoking increased the risk of thrombosis.

CONCLUSION: The current study suggests that smoking may be associated with increased prevalence and severity of MPN symptoms and underscores the need to enhance patient education and address tobacco use in the care of MPN patients.

Original languageEnglish
Article number691
JournalBMC Cancer
Issue number1
Pages (from-to)691
Publication statusPublished - Dec 2021

    Research areas

  • Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Ex-Smokers/statistics & numerical data, Fatigue/diagnosis, Female, Humans, Internet/statistics & numerical data, Male, Middle Aged, Myeloproliferative Disorders/complications, Non-Smokers/statistics & numerical data, Prevalence, Quality of Life, Severity of Illness Index, Smokers/statistics & numerical data, Surveys and Questionnaires/statistics & numerical data, Tobacco Smoking/adverse effects

ID: 70121358