Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of 2D super-resolution ultrasound imaging of the rat renal vasculature using ex vivo micro-computed tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Infants with congenital heart defects have reduced brain volumes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Instrumental variable analysis using offspring BMI in childhood as an indicator of parental BMI in relation to mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Idelalisib in relapsed/refractory diffuse large B-cell lymphoma: results from a Nordic Lymphoma Group phase II trial

    Research output: Contribution to journalLetterResearchpeer-review

  2. Testing Denmark: a Danish Nationwide Surveillance Study of COVID-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Research output: Contribution to journalLetterResearchpeer-review

View graph of relations

MicroRNAs are small regulatory RNAs that are deregulated in a wide variety of human cancers, including different types of B-cell lymphoma. Nevertheless, the feasibility of circulating microRNA for early diagnosis of B-cell lymphoma has not been established. To address the possibility of detecting specific circulating microRNAs years before a B-cell lymphoma is diagnosed, we studied the plasma expression of microRNA first in pre-treatment samples from patients with diffuse large B-cell lymphoma and subsequently in repository samples from blood donors who later developed B-cell lymphomas. In addition, we studied the microRNA expression in the diagnostic lymphoma biopsy. The most strongly induced (miR-326) and suppressed (miR-375) plasma microRNA at diagnosis, when compared with healthy blood donors, were also substantially up- or down-regulated in plasma repository samples taken from several months to up to two years before the blood donors were diagnosed with B-cell lymphoma. Importantly, at these time points the donors had no signs of disease and felt healthy enough to donate blood. In conclusion, this first study of plasma microRNA profiles from apparently healthy individuals, taken several years before B-cell lymphoma diagnosis, suggests that plasma microRNA profiles may be predictive of lymphoma development.

Original languageEnglish
Article number9637
JournalScientific Reports
Volume10
Issue number1
Pages (from-to)9637
ISSN2045-2322
DOIs
Publication statusPublished - 15 Jun 2020

    Research areas

  • Adult, Aged, Aged, 80 and over, Case-Control Studies, Circulating MicroRNA/blood, Early Diagnosis, Female, Humans, Lymphoma, B-Cell/blood, Lymphoma, Large B-Cell, Diffuse/blood, Male, Middle Aged, ROC Curve, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity

ID: 61675141