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Rigshospitalet - a part of Copenhagen University Hospital
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The pathology and aetiology of subcortical clefts in infants

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  1. Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark

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  2. Forensic age estimation from the clavicle using 1.0T MRI--preliminary results

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  1. Leukodystrophy as a feature of PIGT-CDG

    Research output: Contribution to journalLetterResearchpeer-review

  2. First report of the neuropathological findings in a patient with leukodystrophy and compound heterozygous variants in the PIGT gene

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Faroese founder variant in TBCD causes early onset, progressive encephalopathy with a homogenous clinical course

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In infants, traumatic surface contusions of the brain are rare but subcortical clefts or cysts, variously labelled "contusional tears", "contusional clefts", "cortical tears" or "parenchymal lacerations" have been ascribed to trauma, and are even said to be characteristic of shaking and abuse. We describe the pathology of subcortical clefts or haemorrhages in seven infants. In none were the axonal swellings characteristic of traumatic axonal injury seen in relation to the clefts. Subpial bleeding was associated with clefts in all the cases of recent onset. We hypothesize that subcortical clefts are not due to direct mechanical forces of trauma but are part of a secondary cascade caused by impaired venous drainage which may or may not follow trauma. The finding of subcortical and subpial haemorrhages should prompt a search for CVT. We consider the term "contusion" is not accurate and is misleading.

Original languageEnglish
JournalForensic Science International
Volume296
Pages (from-to)115-122
Number of pages8
ISSN0379-0738
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • Brain/blood supply, Brain Contusion, Cerebral Cortex/pathology, Cerebral Hemorrhage/pathology, Cerebrovascular Circulation, Child Abuse/diagnosis, Diagnosis, Differential, Female, Forensic Pathology, Humans, Infant, Infant, Newborn, Male, Pia Mater/pathology, Shaken Baby Syndrome/diagnosis, Terminology as Topic, Venous Insufficiency/pathology, Venous Thrombosis/pathology

ID: 59081717