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Rigshospitalet - a part of Copenhagen University Hospital
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The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pre-transplant levels of ficolin-3 are associated with kidney graft survival

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  3. Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection

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  1. Comparison of 16 Serological SARS-CoV-2 Immunoassays in 16 Clinical Laboratories

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft-tissue infection

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  4. Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

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The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

Original languageEnglish
JournalClinical immunology (Orlando, Fla.)
Volume154
Issue number1
Pages (from-to)13-25
Number of pages13
ISSN1521-6616
DOIs
Publication statusPublished - Sep 2014

    Research areas

  • Complement Pathway, Mannose-Binding Lectin, HIV Infections, Humans, Models, Biological, Polymorphism, Genetic

ID: 44728942