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Rigshospitalet - a part of Copenhagen University Hospital
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The insulin like growth factor system in cirrhosis. Relation to changes in body composition following adrenoreceptor blockade

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  1. Lower levels of placental growth hormone in early pregnancy in women with type 1 diabetes and large for gestational age infants

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  2. Pregnancy-induced increase in circulating IGF-I is associated with progression of diabetic retinopathy in women with type 1 diabetes

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OBJECTIVE: Circulating levels of IGF-I and IGFBP-3 are low in cirrhosis and are related to liver dysfunction. Metabolic disturbances include malnutrition with altered body composition and osteopenia. Since the effects of IGF-I may be associated to changes in body composition and bone mineral content (BMC) in cirrhotic patients, we investigated the relations between changes in the IGF-system and body composition and the effects of long-term alpha- and beta-blockade. DESIGN: The study was designed as a combined cross-sectional and prospective randomised controlled study of 62 patients with cirrhosis. Twenty-three of these patients were randomised to treatment with beta- or combined alpha/beta-blocker for 3months. Haemodynamics, body composition, and systemic and hepatic IGF-I and IGFBP-3 levels were determined in all patients. In the subgroup changes in body composition and IGF-I/IGFBP-3 levels after 3months of beta- or combined alpha/beta-blockade were additionally examined. RESULTS: Both the hepatic and the systemic IGF systems were suppressed and correlated with liver dysfunction and anthropometrics (p
Original languageEnglish
JournalGrowth Hormone & IGF Research
Volume22
Issue number6
Pages (from-to)212-218
Number of pages7
ISSN1096-6374
DOIs
Publication statusPublished - 2012

ID: 36419692