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Rigshospitalet - a part of Copenhagen University Hospital

The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study

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  1. Family involvement in the treatment of patients with an acquired brain injury or malignant brain tumor: a scoping review protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Potentiale for FoC i en tværfaglig praksis

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Background. A major concern in intervention studies is the generalizability of the findings due to refusal of intended participants to actually take part. In studies including ill older people the number of those declining to participate may be large and the concern is therefore relevant. Objectives. To compare patients characteristics, rates of acute readmission, and mortality after one and six months among older persons who agreed and those who declined to participate in a randomized controlled trial and to describe subgroups of nonparticipants. Design. Comparative study based on a randomized controlled trial. Setting. University hospital in the Capital Region of Denmark. Participants. Patients ≥70 years discharged home after a short Emergency Department stay. 399 were requested to participate; 271 consented, whereas 128 refused. Results. Refusers were more likely to be readmitted (p < 0.001) or die (p = 0.006). The largest subgroup of refusers described as "too ill" had the highest risk of readmission (OR = 3.00, 95% CI = 1.61-5.47, p = 0.001) and of mortality within six months (OR = 3.50, 95% CI = 1.64-7.49, p = 0.002). However, this seems not to have affected the results of our randomized study. Conclusion. We recommend that intervention studies among older people or other fragile patient groups include analysis of relevant risk and subgroup analyses of refusers.

Original languageEnglish
Pages (from-to)2787282
Publication statusPublished - 2016

    Research areas

  • Journal Article

ID: 48354128