Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

The impact of HPV genotypes on survival in HPV-positive oropharyngeal squamous cell carcinomas: a systematic review

Research output: Contribution to journalReviewResearchpeer-review

  1. Clinicopathologic characteristics of Burkitt lymphoma of the head and neck in a non-endemic region-a Danish nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Danish translation of the Neck Dissection Impairment Index

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Distribution of microcrack surface density in the human otic capsule

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

    Research output: Contribution to journalReviewResearchpeer-review

  4. Examination of hearing loss among school-aged children in Greenland

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: Patients with HPV-positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) are known to have a better prognosis compared to patients with HPV-negative OPSCCs.

AIMS/OBJECTIVES: To investigate the impact of specific HPV genotypes on survival in HPV + OPSCC.

MATERIAL AND METHODS: A systematic search of PubMed and Embase for studies addressing the association between specific HPV genotypes and survival among patients with OPSCC was performed.

RESULTS: Six studies (n = 1385 patients) published between 2013 and 2017 were included. Five studies (n = 1290 patients) found a better survival among HPV16 cases compared to other high-risk (HR) HPV genotypes (HPV 33, 18, 35, 31, 39, 52, 59, 45, 56, 67, 29, and 58), of which three studies (n = 933 patients) reached significant results. Two of these studies reported a five-year overall survival (OS) of 64.6% and 71.4% in HPV16 OPSCCs vs. 45.6% and 57.1% in HR non-HPV16 OPSCCs (p = .001 and p = .010, respectively), and the last study found a better OS among HPV16 cases with a hazard ratio (HR) of 0.35, 95%. CI [0.14;0.85], p = .02.

CONCLUSIONS: Our findings indicate a favorable prognosis among patients with HPV16 OPSCC compared with HR non-HPV16 OPSCC. These results may be important when designing future trials and in the planning of follow-up regimes.

Original languageEnglish
JournalActa Oto-Laryngologica
Volume141
Issue number7
Pages (from-to)724-728
Number of pages5
ISSN0001-6489
DOIs
Publication statusPublished - Jul 2021

    Research areas

  • genotype, Human papillomaviurs, oropharyngeal squamous cell carcinoma, survival

ID: 67742034