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Rigshospitalet - a part of Copenhagen University Hospital
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The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation

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Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Type 2 diabetes (T2D) is also characterized by immune activation and inflammation. We aimed to investigate the impact of concurrent HIV infection and T2D on T-cell subsets. The study included PLWH with T2D (HIV+T2D+, N = 25) and without T2D (HIV+T2D-, N = 25) and HIV-negative controls with T2D (HIV-T2D+, N = 22) and without T2D (HIV-T2D-, N = 28). All PLWH in the study were receiving combination antiretroviral therapy. We examined T-cell homeostasis by determining T-cell subsets (immune maturation, immune regulation and immune activation) using flow cytometry. HIV+T2D- had lower proportion of Tc17 cells and higher proportion of apoptotic cells than HIV-T2D-. When comparing HIV+T2D+ and HIV+T2D- a lower proportion of CD4+ recent thymic emigrants (RTE) was found (p = 0.028). Furthermore, HIV+T2D+ had a higher proportion of non-suppressive CD4+ Tregs compared to HIV+T2D- (p = 0.010). In conclusion, even in the setting of treated HIV infection, distinct immunological alterations are found. In PLWH with concomitant T2D, most alterations in T-cell subsets were related to HIV and only few differences were found between PLWH with and without diabetes.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number7
Pages (from-to)529-537
Number of pages9
ISSN0903-4641
DOIs
Publication statusPublished - Jul 2019

    Research areas

  • Anti-Retroviral Agents/therapeutic use, CD4-Positive T-Lymphocytes/immunology, Diabetes Mellitus, Type 2/immunology, Female, HIV/drug effects, HIV Infections/drug therapy, Humans, Immunologic Factors/immunology, Middle Aged, chronic immune activation, type 2 diabetes, T-cell homeostasis, inflammation, HIV infection

ID: 58007023