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Rigshospitalet - a part of Copenhagen University Hospital
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The effect of subretinal viscoelastics on the porcine retinal function

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  1. A presentation of culture-positive corneal donors and the effect on clinical outcomes

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  2. "Ant-egg" cataract revisited

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  3. 59 eyes with endogenous endophthalmitis- causes, outcomes and mortality in a Danish population between 2000 and 2016

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  4. Repeated subretinal surgery and removal of subretinal decalin is well tolerated - evidence from a porcine model

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  1. Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment

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  2. Ultra-widefield fundus photography for radiation therapy planning of ocular tumours

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  3. Retinal drawings and distance to foveal involvement in retinal detachments

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  4. The Danish Rural Eye Study: prevalence of strabismus among 3785 Danish adults - a population-based cross-sectional study

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The functional consequence of long-term retinal detachment in the porcine model is examined by multifocal electroretinography (mfERG). Retinal detachment (RD) in humans leaves permanent visual impairment, despite anatomical successful reattachment surgery. To improve treatment, adjuvant pharmaceutical therapy is needed, and can only be tested in a suitable animal model. The porcine model is promising and the mfERG is well validated in this model. RD was induced in 18 pigs by vitrectomy and healon injection of various concentrations. Preoperatively and 6 weeks postoperatively eight animals were examined by mfERG. The major component P1 was analyzed statistically. Indirect ophthalmoscopy and bilateral color fundus photography (FP) were performed. Selected animals underwent high-resolution optical coherence tomography (OCT). Examination by ophthalmoscopy and FP showed that the RDs remained detached for the 6 weeks of follow-up. The P1 amplitude of the mfERG did not differ significantly between the detached areas, the surrounding attached areas, and the healthy eye (p = 0.25). Similarly, P1 implicit time did not differ between the areas (p = 0.85). The lack of functional consequences of long-term RD makes the porcine model unsuitable for examining adjuvant pharmaceutical RD treatment. Future studies should focus on foveated primates.
Original languageEnglish
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume250
Issue number1
Pages (from-to)79-86
Number of pages8
ISSN0721-832X
DOIs
Publication statusPublished - 2012

    Research areas

  • Animals, Disease Models, Animal, Electroretinography, Endotamponade, Female, Hyaluronic Acid, Ophthalmoscopy, Remission, Spontaneous, Retina, Retinal Detachment, Sus scrofa, Tomography, Optical Coherence, Viscosupplements, Vitrectomy

ID: 36816453