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Rigshospitalet - a part of Copenhagen University Hospital
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The effect of pupil size on stimulation of the melanopsin containing retinal ganglion cells, as evaluated by monochromatic pupillometry

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Purpose: To evaluate the influence of the size of the light exposed pupil in one eye on the pupillary light reflex of the other eye. Method: Using a monochromatic pupillometer, the left eye in each of 10 healthy subjects was exposed to 20 s of monochromatic light of luminance 300 cd/m(2), first red (660 nm) and in a following session, blue (470 nm) light. The consensual pupillary diameter in the right eye was continuously measured before, during, and after light exposure. Subsequently, Tropicamide 1% or Pilocarpine 2% was instilled into the left eye and when the pupil was either maximally dilated or contracted, the entire sequence of red and blue light exposure repeated. After at least 3 days, when the effect of the eye drop had subsided, the entire experiment was repeated, this time employing the other substance. Results: Prior dilatation of the left pupil augmented the post light contraction to blue (p 
Original languageEnglish
JournalFrontiers in Neurology
Volume2
Pages (from-to)92
ISSN1664-2295
DOIs
Publication statusPublished - 2012

ID: 33281963