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The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort

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Weis, N, Katzenstein, TL, Ørbæk, M, Storgaard, M, Pedersen, G, Johansen, IS & Moseholm, E 2021, 'The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort', BMJ Open, vol. 11, no. 7, e044565, pp. 1-7. https://doi.org/10.1136/bmjopen-2020-044565

APA

Weis, N., Katzenstein, T. L., Ørbæk, M., Storgaard, M., Pedersen, G., Johansen, I. S., & Moseholm, E. (2021). The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort. BMJ Open, 11(7), 1-7. [e044565]. https://doi.org/10.1136/bmjopen-2020-044565

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MLA

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Author

Weis, Nina ; Katzenstein, Terese L ; Ørbæk, Mathilde ; Storgaard, Merete ; Pedersen, Gitte ; Johansen, Isik S ; Moseholm, Ellen. / The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort. In: BMJ Open. 2021 ; Vol. 11, No. 7. pp. 1-7.

Bibtex

@article{4a6ae2a5fff3465aa5ed12df06f4461d,
title = "The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort",
abstract = "PURPOSE: The purpose of the Danish HIV Birth Cohort (DHBC) is to investigate the significance of HIV-1 infection in pregnancy and after delivery in women living with HIV (WLWH) in Denmark and their children, in the era of antiretroviral therapy and other interventions for treatment and prophylaxis.PARTICIPANTS: All WLWH giving birth to one or more children in Denmark after 31 December 1999 are included, with consecutive ongoing enrolment, if they are living with HIV and pregnant, or if they are diagnosed with HIV in relation to pregnancy, delivery or shortly after delivery.FINDINGS TO DATE: DHBC has been used to describe trends in the management of pregnancies in WLWH and their outcomes on a nationwide basis, mode of delivery and predictors of emergency caesarean section as well as risk factors during pregnancy in WLWH for birth-related complications compared with women from the general population (WGP). We have found that HIV-exposed, but uninfected (HEU) children born to WLWH had a lower median birth weight and gestational age and were at higher risk of intrauterine growth retardation than children born to WGP. We have investigated risk of in-hospital admission and use of antibiotics during the first 4 years of life among HEU children and showed that HEU children had an increased risk of overall hospital admission compared with a matched control group of unexposed children.Further, we compared anthropometric outcomes in children with a matched control group of children not exposed to HIV.FUTURE PLANS: To continuously investigate the significance of HIV infection and antiretroviral therapy in pregnancy and after delivery in WLWH in Denmark and their HEU children and compare these findings with children born to WGP.",
keywords = "epidemiology, HIV & AIDS, reproductive medicine",
author = "Nina Weis and Katzenstein, {Terese L} and Mathilde {\O}rb{\ae}k and Merete Storgaard and Gitte Pedersen and Johansen, {Isik S} and Ellen Moseholm",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = jul,
day = "8",
doi = "10.1136/bmjopen-2020-044565",
language = "English",
volume = "11",
pages = "1--7",
journal = "BMJ Paediatrics Open ",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - The Danish HIV Birth Cohort (DHBC) - a nationwide, prospective cohort

AU - Weis, Nina

AU - Katzenstein, Terese L

AU - Ørbæk, Mathilde

AU - Storgaard, Merete

AU - Pedersen, Gitte

AU - Johansen, Isik S

AU - Moseholm, Ellen

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/7/8

Y1 - 2021/7/8

N2 - PURPOSE: The purpose of the Danish HIV Birth Cohort (DHBC) is to investigate the significance of HIV-1 infection in pregnancy and after delivery in women living with HIV (WLWH) in Denmark and their children, in the era of antiretroviral therapy and other interventions for treatment and prophylaxis.PARTICIPANTS: All WLWH giving birth to one or more children in Denmark after 31 December 1999 are included, with consecutive ongoing enrolment, if they are living with HIV and pregnant, or if they are diagnosed with HIV in relation to pregnancy, delivery or shortly after delivery.FINDINGS TO DATE: DHBC has been used to describe trends in the management of pregnancies in WLWH and their outcomes on a nationwide basis, mode of delivery and predictors of emergency caesarean section as well as risk factors during pregnancy in WLWH for birth-related complications compared with women from the general population (WGP). We have found that HIV-exposed, but uninfected (HEU) children born to WLWH had a lower median birth weight and gestational age and were at higher risk of intrauterine growth retardation than children born to WGP. We have investigated risk of in-hospital admission and use of antibiotics during the first 4 years of life among HEU children and showed that HEU children had an increased risk of overall hospital admission compared with a matched control group of unexposed children.Further, we compared anthropometric outcomes in children with a matched control group of children not exposed to HIV.FUTURE PLANS: To continuously investigate the significance of HIV infection and antiretroviral therapy in pregnancy and after delivery in WLWH in Denmark and their HEU children and compare these findings with children born to WGP.

AB - PURPOSE: The purpose of the Danish HIV Birth Cohort (DHBC) is to investigate the significance of HIV-1 infection in pregnancy and after delivery in women living with HIV (WLWH) in Denmark and their children, in the era of antiretroviral therapy and other interventions for treatment and prophylaxis.PARTICIPANTS: All WLWH giving birth to one or more children in Denmark after 31 December 1999 are included, with consecutive ongoing enrolment, if they are living with HIV and pregnant, or if they are diagnosed with HIV in relation to pregnancy, delivery or shortly after delivery.FINDINGS TO DATE: DHBC has been used to describe trends in the management of pregnancies in WLWH and their outcomes on a nationwide basis, mode of delivery and predictors of emergency caesarean section as well as risk factors during pregnancy in WLWH for birth-related complications compared with women from the general population (WGP). We have found that HIV-exposed, but uninfected (HEU) children born to WLWH had a lower median birth weight and gestational age and were at higher risk of intrauterine growth retardation than children born to WGP. We have investigated risk of in-hospital admission and use of antibiotics during the first 4 years of life among HEU children and showed that HEU children had an increased risk of overall hospital admission compared with a matched control group of unexposed children.Further, we compared anthropometric outcomes in children with a matched control group of children not exposed to HIV.FUTURE PLANS: To continuously investigate the significance of HIV infection and antiretroviral therapy in pregnancy and after delivery in WLWH in Denmark and their HEU children and compare these findings with children born to WGP.

KW - epidemiology

KW - HIV & AIDS

KW - reproductive medicine

UR - http://www.scopus.com/inward/record.url?scp=85109707681&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2020-044565

DO - 10.1136/bmjopen-2020-044565

M3 - Journal article

C2 - 34244252

VL - 11

SP - 1

EP - 7

JO - BMJ Paediatrics Open

JF - BMJ Paediatrics Open

SN - 2044-6055

IS - 7

M1 - e044565

ER -

ID: 66725432