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The circadian rhythm of calcium and bone homeostasis in Maasai

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Schou, Anne ; Jørgensen, Niklas Rye ; Maro, Venance Phillip ; Kilonzo, Kajiru ; Ramaiya, Kaushik ; Sironga, Joseph ; Jensen, Andreas Kryger ; Christensen, Dirk Lund ; Schwarz, Peter. / The circadian rhythm of calcium and bone homeostasis in Maasai. In: American journal of human biology : the official journal of the Human Biology Council. 2022 ; Vol. 34, No. 8. pp. e23756.

Bibtex

@article{94753a0ede7d4aa5b649c367249aaaad,
title = "The circadian rhythm of calcium and bone homeostasis in Maasai",
abstract = "OBJECTIVES: Ethnic groups differ in prevalence of calcium-related diseases. Differences in the physiology and the endogenous circadian rhythm (CR) of calcium and bone homeostasis may play a role. Thus, we aimed to investigate details of CR pattern in calcium and bone homeostasis in East African Maasai.METHODS: Ten clinically healthy adult Maasai men and women from Tanzania were examined. Blood samples were collected every 2nd hour for 24 h. Serum levels of total calcium, albumin, parathyroid hormone (PTH), 25(OH)D, creatinine, C-terminal telopeptide (CTX), bone-specific alkaline phosphatase (BSAP), procollagen type 1 N-terminal propeptide (P1NP), and osteocalcin were measured. Circadian patterns were derived from graphic curves of medians, and rhythmicity was assessed with Fourier analysis.RESULTS: PTH-levels varied over the 24 h exhibiting a bimodal pattern. Nadir level corresponded to 65% of total 24-h mean. CTX and P1NP showed 24-h variations with a morning nadir and nocturnal peak with nadir levels corresponding to 23% and 79% of the 24-h mean, respectively. Albumin-corrected calcium level was held in a narrow range and alterations were corresponding to alterations in PTH. There was no distinct pattern in 24-h variations of 25(OH)D, creatinine, osteocalcin, or BSAP.CONCLUSIONS: All participants showed pronounced 24-h variations in PTH and bone turnover markers CTX and P1NP. These findings support that Maasai participants included in this study have typical patterns of CR in calcium and bone homeostasis consistent with findings from other ethnic populations.",
keywords = "Adult, Albumins, Biomarkers, Bone and Bones/physiology, Calcium/physiology, Circadian Rhythm/physiology, Creatinine, Ethnicity, Female, Homeostasis, Humans, Male, Osteocalcin, Parathyroid Hormone/physiology, Tanzania",
author = "Anne Schou and J{\o}rgensen, {Niklas Rye} and Maro, {Venance Phillip} and Kajiru Kilonzo and Kaushik Ramaiya and Joseph Sironga and Jensen, {Andreas Kryger} and Christensen, {Dirk Lund} and Peter Schwarz",
note = "{\textcopyright} 2022 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.",
year = "2022",
month = aug,
doi = "10.1002/ajhb.23756",
language = "English",
volume = "34",
pages = "e23756",
journal = "American Journal of Human Biology",
issn = "1042-0533",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - The circadian rhythm of calcium and bone homeostasis in Maasai

AU - Schou, Anne

AU - Jørgensen, Niklas Rye

AU - Maro, Venance Phillip

AU - Kilonzo, Kajiru

AU - Ramaiya, Kaushik

AU - Sironga, Joseph

AU - Jensen, Andreas Kryger

AU - Christensen, Dirk Lund

AU - Schwarz, Peter

N1 - © 2022 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.

PY - 2022/8

Y1 - 2022/8

N2 - OBJECTIVES: Ethnic groups differ in prevalence of calcium-related diseases. Differences in the physiology and the endogenous circadian rhythm (CR) of calcium and bone homeostasis may play a role. Thus, we aimed to investigate details of CR pattern in calcium and bone homeostasis in East African Maasai.METHODS: Ten clinically healthy adult Maasai men and women from Tanzania were examined. Blood samples were collected every 2nd hour for 24 h. Serum levels of total calcium, albumin, parathyroid hormone (PTH), 25(OH)D, creatinine, C-terminal telopeptide (CTX), bone-specific alkaline phosphatase (BSAP), procollagen type 1 N-terminal propeptide (P1NP), and osteocalcin were measured. Circadian patterns were derived from graphic curves of medians, and rhythmicity was assessed with Fourier analysis.RESULTS: PTH-levels varied over the 24 h exhibiting a bimodal pattern. Nadir level corresponded to 65% of total 24-h mean. CTX and P1NP showed 24-h variations with a morning nadir and nocturnal peak with nadir levels corresponding to 23% and 79% of the 24-h mean, respectively. Albumin-corrected calcium level was held in a narrow range and alterations were corresponding to alterations in PTH. There was no distinct pattern in 24-h variations of 25(OH)D, creatinine, osteocalcin, or BSAP.CONCLUSIONS: All participants showed pronounced 24-h variations in PTH and bone turnover markers CTX and P1NP. These findings support that Maasai participants included in this study have typical patterns of CR in calcium and bone homeostasis consistent with findings from other ethnic populations.

AB - OBJECTIVES: Ethnic groups differ in prevalence of calcium-related diseases. Differences in the physiology and the endogenous circadian rhythm (CR) of calcium and bone homeostasis may play a role. Thus, we aimed to investigate details of CR pattern in calcium and bone homeostasis in East African Maasai.METHODS: Ten clinically healthy adult Maasai men and women from Tanzania were examined. Blood samples were collected every 2nd hour for 24 h. Serum levels of total calcium, albumin, parathyroid hormone (PTH), 25(OH)D, creatinine, C-terminal telopeptide (CTX), bone-specific alkaline phosphatase (BSAP), procollagen type 1 N-terminal propeptide (P1NP), and osteocalcin were measured. Circadian patterns were derived from graphic curves of medians, and rhythmicity was assessed with Fourier analysis.RESULTS: PTH-levels varied over the 24 h exhibiting a bimodal pattern. Nadir level corresponded to 65% of total 24-h mean. CTX and P1NP showed 24-h variations with a morning nadir and nocturnal peak with nadir levels corresponding to 23% and 79% of the 24-h mean, respectively. Albumin-corrected calcium level was held in a narrow range and alterations were corresponding to alterations in PTH. There was no distinct pattern in 24-h variations of 25(OH)D, creatinine, osteocalcin, or BSAP.CONCLUSIONS: All participants showed pronounced 24-h variations in PTH and bone turnover markers CTX and P1NP. These findings support that Maasai participants included in this study have typical patterns of CR in calcium and bone homeostasis consistent with findings from other ethnic populations.

KW - Adult

KW - Albumins

KW - Biomarkers

KW - Bone and Bones/physiology

KW - Calcium/physiology

KW - Circadian Rhythm/physiology

KW - Creatinine

KW - Ethnicity

KW - Female

KW - Homeostasis

KW - Humans

KW - Male

KW - Osteocalcin

KW - Parathyroid Hormone/physiology

KW - Tanzania

UR - http://www.scopus.com/inward/record.url?scp=85128951504&partnerID=8YFLogxK

U2 - 10.1002/ajhb.23756

DO - 10.1002/ajhb.23756

M3 - Journal article

C2 - 35481615

VL - 34

SP - e23756

JO - American Journal of Human Biology

JF - American Journal of Human Biology

SN - 1042-0533

IS - 8

M1 - e23756

ER -

ID: 77847419