Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

TESTICULAR GROWTH DURING PUBERTY IN BOYS WITH AND WITHOUT A HISTORY OF CONGENITAL CRYPTORCHIDISM

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Longitudinal Increases in Serum Insulin-like Factor 3 and Testosterone Determined by LC-MS/MS in Pubertal Danish Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Marked increase in incident gynecomastia: a 20-year national registry study, 1998 to 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. DIAGNOSIS OF ENDOCRINE DISEASE: Sex steroid action in adolescence: too much, too little; too early, too late

    Research output: Contribution to journalReviewResearchpeer-review

  2. Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

CONTEXT: The pattern of testicular growth during puberty may provide important information about early testicular damage and reproductive potential in adulthood.

OBJECTIVE: To evaluate pubertal testicular growth in boys with congenital cryptorchidism and controls.

DESIGN: Longitudinal case-control study.

SETTING: Andrological Research Center, University of Turku.

PARTICIPANTS: Altogether 119 boys participated: 51 cases with a history of congenital cryptorchidism and 65 controls fulfilled the inclusion criteria.

INTERVENTION: None.

MAIN OUTCOME MEASURES: Testicular volume by an orchidometer (mL) and ultrasound (mL), testicular length by a ruler (mm), onset of pubertal testicular growth (years). Longitudinal testicular growth was analyzed with a nonlinear mixed-effect model.

RESULTS: The mean age of the onset of pubertal testicular growth (age at the attainment of >3 mL by orchidometer) was 11.7 and 11.8 years in cryptorchid cases and controls, respectively. The difference between cases and controls was not significant. Modeled postpubertal testicular size was smaller among bilaterally and unilaterally undescended testis than in controls. There was a high level of agreement between testicular sizes of 3 mL by orchidometer and 25 mm by ruler as cut-offs in definition of the onset of puberty. An orchidometer size of 3 mL and ruler length of 25 mm corresponded to 1.6 and 1.7 mL by ultrasound (with Lambert's formula), respectively.

CONCLUSIONS: Testicular growth in puberty was impaired in congenitally cryptorchid boys. This suggests a poor perinatal development of the cryptorchid testis. The timing of the onset of pubertal testicular growth, however, did not differ which suggests an intact hypothalamic-pituitary axis.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume101
Issue number6
Pages (from-to)2570-7
ISSN0021-972X
DOIs
Publication statusPublished - 6 Apr 2016

ID: 46427176