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Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study

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Lima, RA, Desoye, G, Simmons, D, Devlieger, R, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Harreiter, J, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, L-L, Tanvig, M, Lapolla, A, Dalfra, MG, Bertolotto, A, Wender-Ozegowska, E, Zawiejska, A, Hill, DJ, Snoek, FJ, Jelsma, JGM & van Poppel, MNM 2020, 'Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study' Pediatric obesity, vol. 15, no. 7, e12628, pp. e12628. https://doi.org/10.1111/ijpo.12628

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CBE

Lima RA, Desoye G, Simmons D, Devlieger R, Galjaard S, Corcoy R, Adelantado JM, Dunne F, Harreiter J, Kautzky-Willer A, Damm P, Mathiesen ER, Jensen DM, Andersen L-L, Tanvig M, Lapolla A, Dalfra MG, Bertolotto A, Wender-Ozegowska E, Zawiejska A, Hill DJ, Snoek FJ, Jelsma JGM, van Poppel MNM. 2020. Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study. Pediatric obesity. 15(7):e12628. https://doi.org/10.1111/ijpo.12628

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Author

Lima, Rodrigo A ; Desoye, Gernot ; Simmons, David ; Devlieger, Roland ; Galjaard, Sander ; Corcoy, Rosa ; Adelantado, Juan M ; Dunne, Fidelma ; Harreiter, Jürgen ; Kautzky-Willer, Alexandra ; Damm, Peter ; Mathiesen, Elisabeth R ; Jensen, Dorte M ; Andersen, Lise-Lotte ; Tanvig, Mette ; Lapolla, Annunziata ; Dalfra, Maria G ; Bertolotto, Alessandra ; Wender-Ozegowska, Ewa ; Zawiejska, Agnieszka ; Hill, David J ; Snoek, Frank J ; Jelsma, Judith G M ; van Poppel, Mireille N M. / Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex : Secondary analysis of the DALI study. In: Pediatric obesity. 2020 ; Vol. 15, No. 7. pp. e12628.

Bibtex

@article{7a17313f19a849588cbc3e5e5bf8d76d,
title = "Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study",
abstract = "Objectives: To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. Methods: This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m 2 were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. Results: In total, 458 mother-infant pairs (50.2{\%} female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Conclusions: Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.",
keywords = "Adiposity, Adult, Female, Gestational Age, Humans, Infant, Newborn, Longitudinal Studies, Male, Obesity, Maternal/metabolism, Pregnancy, Sex Characteristics",
author = "Lima, {Rodrigo A} and Gernot Desoye and David Simmons and Roland Devlieger and Sander Galjaard and Rosa Corcoy and Adelantado, {Juan M} and Fidelma Dunne and J{\"u}rgen Harreiter and Alexandra Kautzky-Willer and Peter Damm and Mathiesen, {Elisabeth R} and Jensen, {Dorte M} and Lise-Lotte Andersen and Mette Tanvig and Annunziata Lapolla and Dalfra, {Maria G} and Alessandra Bertolotto and Ewa Wender-Ozegowska and Agnieszka Zawiejska and Hill, {David J} and Snoek, {Frank J} and Jelsma, {Judith G M} and {van Poppel}, {Mireille N M}",
note = "{\circledC} 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.",
year = "2020",
month = "7",
doi = "10.1111/ijpo.12628",
language = "English",
volume = "15",
pages = "e12628",
journal = "International Journal of Pediatric Obesity",
issn = "1524-6817",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "7",

}

RIS

TY - JOUR

T1 - Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex

T2 - Secondary analysis of the DALI study

AU - Lima, Rodrigo A

AU - Desoye, Gernot

AU - Simmons, David

AU - Devlieger, Roland

AU - Galjaard, Sander

AU - Corcoy, Rosa

AU - Adelantado, Juan M

AU - Dunne, Fidelma

AU - Harreiter, Jürgen

AU - Kautzky-Willer, Alexandra

AU - Damm, Peter

AU - Mathiesen, Elisabeth R

AU - Jensen, Dorte M

AU - Andersen, Lise-Lotte

AU - Tanvig, Mette

AU - Lapolla, Annunziata

AU - Dalfra, Maria G

AU - Bertolotto, Alessandra

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Hill, David J

AU - Snoek, Frank J

AU - Jelsma, Judith G M

AU - van Poppel, Mireille N M

N1 - © 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.

PY - 2020/7

Y1 - 2020/7

N2 - Objectives: To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. Methods: This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m 2 were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. Results: In total, 458 mother-infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Conclusions: Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.

AB - Objectives: To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. Methods: This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre-pregnancy body mass index (BMI) of ≥29 kg/m 2 were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. Results: In total, 458 mother-infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA-index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Conclusions: Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time-dependency is different between sexes, suggesting different growth strategies.

KW - Adiposity

KW - Adult

KW - Female

KW - Gestational Age

KW - Humans

KW - Infant, Newborn

KW - Longitudinal Studies

KW - Male

KW - Obesity, Maternal/metabolism

KW - Pregnancy

KW - Sex Characteristics

UR - http://www.scopus.com/inward/record.url?scp=85080948028&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12628

DO - 10.1111/ijpo.12628

M3 - Journal article

VL - 15

SP - e12628

JO - International Journal of Pediatric Obesity

JF - International Journal of Pediatric Obesity

SN - 1524-6817

IS - 7

M1 - e12628

ER -

ID: 60966278