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Rigshospitalet - a part of Copenhagen University Hospital
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T-cell ALL in ataxia telangiectasia cured with only 7 weeks of anti-leukemic therapy

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A 20-month-old girl diagnosed with T-cell acute lymphoblastic leukemia was treated according to the Nordic NOPHO ALL2000 protocol. The patient developed severe immunosuppression and experienced life-threatening adenovirus infection, which was treated with ribavirin and cidofovir. α-fetoprotein was 20- to 30-fold elevated, and genetic analysis confirmed the diagnosis of ataxia telangiectasia. Despite receiving only 7 weeks of anti-leukemic therapy, she has stayed in first remission now 8 years after the diagnosis. We speculate that this could be because of increased chemosensitivity of ATM-mutated leukemic cells, adenovirus causing a direct oncolytic effect, and/or high levels of endogenous cortisol during her severe infection.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number2
Pages (from-to)154-5
Number of pages2
ISSN1077-4114
DOIs
Publication statusPublished - Mar 2015

    Research areas

  • Adenoviridae, Adenovirus Infections, Human, Antiviral Agents, Ataxia Telangiectasia, Female, Humans, Infant, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Remission Induction

ID: 46275455