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Rigshospitalet - a part of Copenhagen University Hospital
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Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

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Single-cell RNA sequencing (scRNA-seq) is a novel method enabling genetic characterization of tumor tissue at a single-cell level. This study systematically reviewed the literature on studies using scRNA-seq to characterize head and neck squamous cell carcinomas (HNSCCs). Seven studies were included, of which two studies performed scRNA-seq on 20 patients in total, and five studies used scRNA-seq data in a subsequent clinical study. The former mentioned two studies found intra-tumoral genetic heterogeneity among malignant cells but genetic uniformity among non-malignant cells. The five latter studies used scRNA-seq data in various ways. Three studies identified biomarkers related to predicting whether a patient would benefit from immunotherapeutic treatment. One study characterized genes related to the perineural invasion. One study identified genes to be used in diagnostics. Further studies performing scRNA-seq on HNSCC are required to continue the ongoing development and use of scRNA-seq.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume129
Issue number11
Pages (from-to)619-625
Number of pages7
ISSN0903-4641
DOIs
Publication statusPublished - Nov 2021

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • Biomarkers, Tumor/genetics, Gene Expression Profiling, Genetic Heterogeneity, Head and Neck Neoplasms/genetics, Humans, Sequence Analysis, RNA, Single-Cell Analysis, Squamous Cell Carcinoma of Head and Neck/genetics, Tumor Microenvironment/genetics

ID: 67842985