Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Supplemental oxygen therapy in trauma patients: an exploratory registry-based study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Exploring the limits of prolonged apnoea with high-flow nasal oxygen: an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Measurements of cardiac output and management of blood transfusions during burn surgery - an observational prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sequelae of Major Trauma Patients with Maxillofacial Fractures

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The usefulness of a trauma probability of survival model for forensic life-threatening danger assessments

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Supplemental oxygen (SO) is one of the most commonly administered drugs in trauma patients and is recommended by guidelines. However, evidence supporting uniform administration is sparse, and excess oxygen use has been shown to be harmful in other patient populations. We hypothesized that SO may be harmful in patients with oxygen saturation>97%.

METHODS: Patients with available information on SO-therapy in the American Trauma Quality Improvement Program 2017 database were included. Patients were categorized into three groups according to Emergency Department (ED) oxygen saturation: 1) Saturation<94%; 2) Saturation 94-97%; 3) Saturation 98-100%. Primary outcome was in-hospital mortality with comparisons made between patients who received SO or not. Secondary outcome was acute respiratory distress syndrome (ARDS). Patients were compared after propensity score matching.

RESULTS: Overall, 864,340 patients were identified. Mean age was 47.4 ± 24.4 years and median injury severity score was 9. SO was associated with an increased risk of in-hospital mortality: (all patients: adjusted odds ratio (aOR) with 95% confidence interval (CI) 3.07 [2.92-3.22], ED saturation <94%: 2.63 [2.38-2.91], ED saturation 94%-97%: 2.71 [2.47-2.97], ED saturation >97%: 3.38 [3.16-3.61]. Same pattern was seen for in-hospital ARDS: (aOR 1.79, 95% CI [1.59-2.02], ED saturation <94%: aOR 1.75, 95% CI 1.37-2.24, ED saturation 94%-97%: aOR 1.81, 95% CI 1.43-2.29, ED saturation >97%: aOR 2.31, 95% CI 1.92-2.79).

CONCLUSION: Based on propensity matched, registry data for trauma patients, the administration of SO was associated with a higher incidence of in-hospital mortality and ARDS. The highest risk was found in patients with an ED saturation >97%.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
ISSN0001-5172
DOIs
Publication statusE-pub ahead of print - 11 Apr 2021

ID: 64826622