Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Super-Resolution Imaging with Ultrasound for Visualization of the Renal Microvasculature in Rats Before and After Renal Ischemia: A Pilot Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Preoperative Embolization of a Solitary Fibrous Tumor Originating from External Auditory Meatus: A Case Report with Literature Review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  4. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Preoperative Embolization of a Solitary Fibrous Tumor Originating from External Auditory Meatus: A Case Report with Literature Review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Flow Complexity Estimation in Dysfunctional Arteriovenous Dialysis Fistulas using Vector Flow Imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Postembolization Syndrome after Prostatic Artery Embolization: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

In vivo monitoring of the microvasculature is relevant since diseases such as diabetes, ischemia, or cancer cause microvascular impairment. Super-resolution ultrasound imaging allows in vivo examination of the microvasculature by detecting and tracking sparsely distributed intravascular microbubbles over a minute-long period. The ability to create detailed images of the renal vasculature of Sprague-Dawley rats using a modified clinical ultrasound platform was investigated in this study. Additionally, we hypothesized that early ischemic damage to the renal microcirculation could be visualized. After a baseline scan of the exposed kidney, 10 rats underwent clamping of the renal vein (n = 5) or artery (n = 5) for 45 min. The kidneys were rescanned at the onset of clamp release and after 60 min of reperfusion. Using a processing pipeline for tissue motion compensation and microbubble tracking, super-resolution images with a very high level of detail were constructed. Image filtration allowed further characterization of the vasculature by isolating specific vessels such as the ascending vasa recta with a 15-20 μm diameter. Using the super-resolution images alone, it was only possible for six assessors to consistently distinguish the healthy renal microvasculature from the microvasculature at the onset of vein clamp release. Future studies will aim at attaining quantitative estimations of alterations in the renal microvascular blood flow using super-resolution ultrasound imaging.

Original languageEnglish
JournalDiagnostics
Volume10
Issue number11
Pages (from-to)862
ISSN2075-4418
DOIs
Publication statusPublished - 22 Oct 2020

ID: 61290272