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Rigshospitalet - a part of Copenhagen University Hospital
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Substantial molecular evolution and mutation rates in prolonged latent Mycobacterium tuberculosis infection in humans

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  1. A snapshot of diversity: Intraclonal variation of Escherichia coli clones as commensals and pathogens

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  2. Whole-genome comparison of urinary pathogenic Escherichia coli and faecal isolates of UTI patients and healthy controls

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  3. Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum

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  1. Classification of patients referred under suspicion of tick-borne diseases, Copenhagen, Denmark

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  2. CT and MR neuroimaging findings in patients with Lyme neuroborreliosis: A national prospective cohort study

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  3. Renal function in Ethiopian HIV-positive adults on antiretroviral treatment with and without tenofovir

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  • Troels Lillebaek
  • Anders Norman
  • Erik Michael Rasmussen
  • Rasmus L Marvig
  • Dorte Bek Folkvardsen
  • Åse Bengård Andersen
  • Lars Jelsbak
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The genome of Mycobacterium tuberculosis (Mtb) of latently infected individuals may hold the key to understanding the processes that lead to reactivation and progression to clinical disease. We report here analysis of pairs of Mtb isolates from putative prolonged latent TB cases. We identified two confirmed cases, and used whole genome sequencing to investigate the mutational processes that occur over decades in latent Mtb. We found an estimated mutation rate between 0.2 and 0.3 over 33 years, suggesting that latent Mtb accumulates mutations at rates similar to observations from cases of active disease.

Original languageEnglish
JournalInternational journal of medical microbiology : IJMM
Volume306
Issue number7
Pages (from-to)580-585
Number of pages6
ISSN1438-4221
DOIs
Publication statusPublished - Nov 2016

ID: 49201667