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Rigshospitalet - a part of Copenhagen University Hospital
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Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

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People with human immunodeficiency virus (HIV) infection (PWH) have an increased risk of cardiovascular disease (CVD), compared with the general population. In a nested case-control study of 55 PWH with first-time myocardial infarction (MI; cases) and 182 PWH with no CVD (controls), we measured soluble markers of interleukin 1 (IL-1) activation at 4 different time points before the case's MI. Cases had higher levels of IL-1 receptor antagonist (IL-1Ra) at all time points leading up to first-time MI, and higher levels of IL-1Ra were associated with an approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation to reduce cardiovascular risk in PWH.

Original languageEnglish
JournalThe Journal of infectious diseases
Volume221
Issue number4
Pages (from-to)506-509
Number of pages4
ISSN0022-1899
DOIs
Publication statusPublished - 3 Feb 2020

    Research areas

  • cytokines, HIV, IL-1Ra, IL-1β, myocardial infarction

ID: 57149819