Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Response to Aviv et al

    Research output: Contribution to journalLetterResearchpeer-review

  1. Effect of liraglutide on expression of inflammatory genes in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence and impact of parvovirus B19 infection in seronegative solid organ transplant recipients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

People with human immunodeficiency virus (HIV) infection (PWH) have an increased risk of cardiovascular disease (CVD), compared with the general population. In a nested case-control study of 55 PWH with first-time myocardial infarction (MI; cases) and 182 PWH with no CVD (controls), we measured soluble markers of interleukin 1 (IL-1) activation at 4 different time points before the case's MI. Cases had higher levels of IL-1 receptor antagonist (IL-1Ra) at all time points leading up to first-time MI, and higher levels of IL-1Ra were associated with an approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation to reduce cardiovascular risk in PWH.

Original languageEnglish
JournalThe Journal of infectious diseases
Volume221
Issue number4
Pages (from-to)506-509
Number of pages4
ISSN0022-1899
DOIs
Publication statusPublished - 15 Feb 2020

    Research areas

  • cytokines, HIV, IL-1Ra, IL-1β, myocardial infarction, IL-1 beta

ID: 57149819