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Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Soluble markers of IL-1 activation as predictors of first-time smyocardial infarction in HIV-infected individuals

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People with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to the general population. In a nested case-control study of 55 PWH with first-time Myocardial Infarction (MI) (cases) and 182 PWH with no CVD (controls), we measured soluble markers of IL-1 activation at 4 different timepoints before the case´s MI. Cases had higher levels of IL-1Ra at all time-points leading up to first-time MI, and higher levels of IL-1Ra were associated with approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation in order to reduce cardiovascular risk in PWH.

Original languageEnglish
JournalThe Journal of infectious diseases
ISSN0022-1899
DOIs
Publication statusE-pub ahead of print - 11 May 2019

ID: 57149819