Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Atypical sleep in critically ill patients on mechanical ventilation is associated with increased mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Answer to "On the importance of polysomnography after stroke"

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Polysomnographic indicators of mortality in stroke patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Brain tumours in children and adolescents may affect the circadian rhythm and quality of life

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Workforce Attachment after Ischemic Stroke – The Importance of Time to Thrombolytic Therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Sleep-disordered breathing (SDB) occurs frequently after stroke and is associated with poor functional outcome and increased mortality. The purpose of this study was to detect changes in SDB over time after acute ischemic stroke and investigate relationships between SDB and stroke etiologies with focus on cerebral small vessel disease.

METHODS: From May 2015 to August 2016, we conducted an observational study of 99 patients with mild to moderate stroke (median age: 68 years, range 36-88; 56% men). Polysomnography was performed within 7 days of stroke onset (n = 91) and after 6 months (n = 52). The strokes were classified using the etiological TOAST classification. Total small vessel disease (SVD) scores were calculated based on MRIs.

RESULTS: SDB, defined as an apnea-hypopnea index (AHI) ≥ 15, was found in 56% of patients in the acute state and in 44% at follow-up. AHI decreased over time (median change 4.7, 95% confidence interval [95% CI] 0.5-8.9; p = 0.03). Patients with AHI ≥ 15 in both the acute state and at follow-up had higher SVD score at follow-up (p = 0.003). AHI was not associated with ischemic stroke subgroups according to the TOAST classification.

DISCUSSION: In conclusion, 6 months after stroke, AHI decreased, but 44% still had AHI ≥ 15. Persistent SDB in both the acute state and at follow-up was associated with a higher SVD score, but not to the TOAST subgroups. SDB evaluation should be offered to stroke patients, and the effect of SDB on cerebral small vessel disease needs to be further investigated using the well-defined SVD score.

TRIAL REGISTRATION: clinicaltrials.gov NCT02111408, April 11, 2014.

Original languageEnglish
JournalSleep & breathing = Schlaf & Atmung
ISSN1520-9512
DOIs
Publication statusPublished - 2021

Bibliographical note

© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

    Research areas

  • Cerebral small vessel disease, Ischemic stroke, Sleep apnea, Sleep-disordered breathing

ID: 67851721