Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Sinus surgery can improve quality of life, lung infections, and lung function in patients with primary ciliary dyskinesia

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The Controversies and Difficulties of Diagnosing Primary Ciliary Dyskinesia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dynamic soft tissue changes in the orbit after a blowout fracture

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Chronic rhinosinusitis (CRS) and bacterial sinusitis are ubiquitous in patients with primary ciliary dyskinesia (PCD). From the sinuses, Pseudomonas aeruginosa can infect the lungs.

METHODS: We studied the effect of endoscopic sinus surgery (ESS) on symptoms of CRS and lower airway infections in PCD patients in a prospective single-arm intervention study of ESS with adjuvant therapy using nasal irrigation with saline, topical nasal steroids, and 2 weeks of systemic antibiotics. Additional treatment with local colistin for 6 months was instigated when P. aeruginosa was cultured at ESS.

RESULTS: Twenty-four PCD patients underwent ESS to search for an infectious focus (n = 10), due to severe symptoms of CRS (n = 8), or both (n = 6). Bacteria were cultured from sinus samples in 21 patients (88%), and simultaneous sinus and lung colonization with identical pathogens were observed in 13 patients (62%). Four patients with preoperative P. aeruginosa lung colonization (25%) had no regrowth during follow-up; 2 of these had P. aeruginosa sinusitis. Sinonasal symptoms were improved 12 months after ESS and we observed a trend toward better lung function after ESS.

CONCLUSION: We demonstrated an improvement in CRS-related symptoms after ESS and adjuvant therapy. In selected PCD patients, the suggested regimen may postpone chronic lung infection with P. aeruginosa and stabilize lung function.

Original languageEnglish
JournalInternational forum of allergy & rhinology
Volume7
Issue number3
Pages (from-to)240-247
ISSN2042-6976
DOIs
Publication statusPublished - 2017

ID: 49659934