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Rigshospitalet - a part of Copenhagen University Hospital
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Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells

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DOI

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Transcriptional targeted suicide gene (SG) therapy driven by the insulinoma-associated 1 (INSM1) promoter makes it possible to target suicide toxin production and cytotoxicity exclusively to small cell lung cancer (SCLC) cells and tumors. It remains to be determined whether acquired chemoresistance, as observed in the majority of SCLC patients, desensitizes SCLC cells to INSM1 promoter-driven SG therapy.
Original languageEnglish
JournalThe journal of gene medicine
Volume14
Issue number7
Pages (from-to)445-58
Number of pages14
ISSN1943-961X
DOIs
Publication statusPublished - 2012

    Research areas

  • Animals, Apoptosis, Cell Line, Tumor, Cell Survival, Chemotherapy, Adjuvant, Cytosine Deaminase, Drug Resistance, Neoplasm, Drug Therapy, Combination, Escherichia coli, Flucytosine, Genes, Transgenic, Suicide, Genetic Therapy, Humans, Lung Neoplasms, Male, Mice, Nitroreductases, Pentosyltransferases, Promoter Regions, Genetic, Repressor Proteins, Small Cell Lung Carcinoma, Yeasts

ID: 36590835