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Rigshospitalet - a part of Copenhagen University Hospital
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Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia

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  1. Dynamic soft tissue changes in the orbit after a blowout fracture

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  2. Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas

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  3. Indications, risk of lower airway infection, and complications to pediatric tracheotomy: report from a tertiary referral center

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  1. Dynamic soft tissue changes in the orbit after a blowout fracture

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

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  3. Near-infrared fluorescence imaging improves the nodal yield in neck dissection in oral cavity cancer - A randomized study

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  4. Perspektiver på recidiverende respiratorisk papillomatose og humant papillomvirus-vaccination

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  5. PET/CT prior to salvage surgery in recurrent head and neck squamous cell carcinoma

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UNLABELLED: Abstract Conclusion: The sinuses should be considered as a bacterial reservoir and a target for surgery and antibiotic treatment in patients with primary ciliary dyskinesia (PCD). The observed decrease in serum precipitating antibodies (precipitins) against Pseudomonas aeruginosa may indicate a beneficial effect of combined endoscopic sinus surgery (ESS) and concomitant medical treatment.

OBJECTIVES: The purpose of this research, which is the first study addressing bacteriology in the sinuses of patients with PCD, was to examine the association between sinus and lung infections.

METHODS: We reviewed findings of bacterial pathogens from the sinuses obtained during ESS and the lung infection status in eight PCD patients over a 6 year period. Precipitins against P. aeruginosa were used as a marker of severity of chronic infection and effect of treatment.

RESULTS: Preoperatively, seven of the eight patients (88%) exhibited intermittent or chronic pulmonary infection with P. aeruginosa. Sinus cultures were obtained during ESS in seven patients. The sinuses were colonized with P. aeruginosa in four of seven patients (57%). Bacterial sinusitis was found in five of seven patients (71%) and the same bacterium was found in the sinuses and lungs in all cases. Decreasing precipitins against P. aeruginosa were observed postoperatively in three of four evaluable patients.

Original languageEnglish
JournalActa Oto-Laryngologica
Volume135
Issue number1
Pages (from-to)58-63
Number of pages6
ISSN0001-6489
DOIs
Publication statusPublished - Jan 2015

ID: 44828335