Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Sildenafil and calcitonin gene-related peptide dilate intradural arteries: A 3T MR angiography study in healthy volunteers

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Letter to the editor regarding "Have you ever experienced a headache of any kind?"

    Research output: Contribution to journalLetterResearchpeer-review

  2. Vancouver Declaration II on Global Headache Patient Advocacy 2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Low frequency activation of the sphenopalatine ganglion does not induce migraine-like attacks in migraine patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. No central action of CGRP antagonising drugs in the GTN mouse model of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Vancouver Declaration II on Global Headache Patient Advocacy 2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Low frequency activation of the sphenopalatine ganglion does not induce migraine-like attacks in migraine patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ictal neck pain investigated in the interictal state - a search for the origin of pain

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Neck pain and headache after whiplash injury: a systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background Sildenafil and calcitonin gene-related peptide are vasoactive substances that induce migraine attacks in patients. The intradural arteries are thought to be involved, but these have never been examined in vivo. Sildenafil is the only migraine-inducing compound for which cephalic, extracranial artery dilation is not reported. Here, we investigate the effects of sildenafil and calcitonin gene-related peptide on the extracranial and intradural parts of the middle meningeal artery. Methods In a double-blind, randomized, three-way crossover, placebo-controlled head-to-head comparison study, MR-angiography was recorded in healthy volunteers at baseline and twice after study drug (sildenafil/ calcitonin gene-related peptide/saline) administration. Circumferences of extracranial and intradural middle meningeal artery segments were measured using semi-automated analysis software. The area under the curve for circumference change was compared using paired t-tests between study days. Results Twelve healthy volunteers completed the study. The area under the curveBaseline-120min was significantly larger on both the sildenafil and the calcitonin gene-related peptide day in the intradural middle meningeal artery (calcitonin gene-related peptide, p = 0.013; sildenafil, p = 0.027) and the extracranial middle meningeal artery (calcitonin gene-related peptide, p = 0.0003; sildenafil, p = 0.021), compared to placebo. Peak intradural middle meningeal artery dilation was 9.9% (95% CI [2.9-16.9]) after sildenafil (T30min) and 12.5% (95% CI [8.1-16.8]) after calcitonin gene-related peptide (T30min). Peak dilation of the extracranial middle meningeal artery after calcitonin gene-related peptide (T30min) was 15.7% (95% CI [11.2-20.1]) and 18.9% (95% CI [12.8-24.9]) after sildenafil (T120min). Conclusion An important novel finding is that both sildenafil and calcitonin gene-related peptide dilate intradural arteries, supporting the notion that all known pharmacological migraine triggers dilate cephalic vessels. We suggest that intradural artery dilation is associated with headache induced by calcitonin gene-related peptide and sildenafil.

Original languageEnglish
JournalCephalalgia
Volume39
Issue number2
Pages (from-to)264-273
Number of pages10
ISSN0333-1024
DOIs
Publication statusPublished - Feb 2019

    Research areas

  • human migraine models, middle meningeal artery, Neuroimaging

ID: 54888897