Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Short-Term Flow Changes in Monochorionic Survivor Twins after Ultrasound-Guided Umbilical Cord Occlusion

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Intrathecal IgM as a Prognostic Marker in Multiple Sclerosis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Cell-Free Fetal DNA in the Early and Late First Trimester

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prenatal detection rate of major congenital heart defects in Copenhagen from 2015 to 2018

    Research output: Contribution to journalLetterResearchpeer-review

  2. Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Long-term consequences of prenatal progesterone exposure

    Research output: Contribution to journalComment/debateResearchpeer-review

  4. National data on the early clinical use of non-invasive prenatal testing in public and private healthcare in Denmark 2013-2017

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To determine hemodynamic changes by Doppler ultrasound of the living fetus during 24 h after umbilical cord occlusion (UCO) in monochorionic diamniotic (MCDA) twin pregnancies.

METHOD: We conducted a prospective observational study on fetuses undergoing UCO from 2015 to 2017. Doppler parameters peak systolic velocity (PSV) and umbilical pulsatility index (PI) were obtained in the middle cerebral artery (MCA), umbilical artery (UA) and ductus venosus (DV) before and right after UCO, and at 1, 3, 6, 12, and 24 h after. We used multiple of the median (MoM) to adjust for gestational age. Spaghetti plots visualized flow changes over time. Mixed model adjusting for paired longitudinal data compared the values at different time points.

RESULTS: A total of 16 women were included. MCA-PSV dropped within the first hour after surgery from 0.91 to 0.82 MoM (p = 0.08). MCA-PI and UA-PI increased in the first hour from 0.75 to 0.91 MoM (p = 0.02) and 0.94 to 0.98 MoM (p = 0.22), respectively. The DV-PIV increased to 1.14 MoM 3 h after surgery (p = 0.07). The spaghetti plots illustrated the small changes within the first hours and showed a stabilization of flow measurements near initial values 24 h after UCO.

CONCLUSION: Within the first hours after UCO the circulation of the survivor twin undergoes small hemodynamic changes.

Original languageEnglish
JournalFetal Diagnosis and Therapy
Volume47
Issue number1
Pages (from-to)45-53
Number of pages9
ISSN1015-3837
DOIs
Publication statusPublished - 1 Jan 2020

    Research areas

  • Anemia, Cerebroplacental ratio, Doppler measurements, Ductus venosus, Middle cerebral artery, Monochorionictwins, Peak systolic velocity, Selective feticide, Umbilical artery, Umbilical cord occlusion

ID: 58966727