Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Severity of anaemia and association with all-cause mortality in patients with medically managed left-sided endocarditis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Temporal trends and sex differences in sudden cardiac death in the Copenhagen City Heart Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Socioeconomic disparities in prehospital factors and survival after out-of-hospital cardiac arrest

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Variations in knowledge, awareness and treatment of hypertension and stroke risk by country income level

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Global longitudinal strain predicts cardiovascular events after coronary artery bypass grafting

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To assess the prevalence and severity of anaemia in patients with left-sided infective endocarditis (IE) and association with mortality.

METHODS: In the Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis trial, 400 patients with IE were randomised to conventional or partial oral antibiotic treatment after stabilisation of infection, showing non-inferiority. Haemoglobin (Hgb) levels were measured at randomisation. Primary outcomes were all-cause mortality after 6 months and 3 years. Patients who underwent valve surgery were excluded due to competing reasons for anaemia.

RESULTS: Out of 400 patients with IE, 248 (mean age 70.6 years (SD 11.1), 62 women (25.0%)) were medically managed; 37 (14.9%) patients had no anaemia, 139 (56.1%) had mild anaemia (Hgb <8.1 mmol/L in men and Hgb <7.5 mmol/L in women and Hgb ≥6.2 mmol/L) and 72 (29.0%) had moderate to severe anaemia (Hgb <6.2 mmol/L). Mortality rates in patients with no anaemia, mild anaemia and moderate to severe anaemia were 2.7%, 3.6% and 15.3% at 6-month follow-up and 13.5%, 20.1% and 34.7% at 3-year follow-up, respectively. Moderate to severe anaemia was associated with higher mortality after 6 months (HR 4.81, 95% CI 1.78 to 13.0, p=0.002) and after 3 years (HR 2.14, 95% CI 1.27 to 3.60, p=0.004) and remained significant after multivariable adjustment.

CONCLUSION: Moderate to severe anaemia was present in 29% of patients with medically treated IE after stabilisation of infection and was independently associated with higher mortality within the following 3 years. Further investigations are warranted to determine whether intensified treatment of anaemia in patients with IE might improve outcome.

Original languageEnglish
JournalHeart (British Cardiac Society)
ISSN1355-6037
DOIs
Publication statusE-pub ahead of print - 5 Oct 2021

Bibliographical note

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 68085784