Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Serum levels of C-reactive protein in adolescents with periodontitis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Pattern recognition receptor polymorphisms in early periodontitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Influence of periodontal treatment on subgingival and salivary microbiotas

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of Periodontitis Case Criteria: A Cross-Sectional Study of Lifestyle

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Pattern recognition receptor polymorphisms in early periodontitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Biological anti-TNF drugs: immunogenicity underlying treatment failure and adverse events

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations
Background: The results of several cross-sectional studies suggested a relationship between periodontitis and higher serum levels of C-reactive protein (CRP). Most of these studies were restricted to adult study groups with severe periodontal inflammation, and the potential effects of confounding factors were frequently overlooked. Methods: A case-referent study comprised of 87 adolescent cases who presented with clinical attachment loss ≥3 mm recorded in ≥2 of 16 teeth and 73 controls who did not fulfill these criteria was nested in a fully enumerated adolescent population. Venous blood samples were obtained, and CRP levels were quantified, using a high-sensitive bead-based flow cytometric assay. The Mann-Whitney U test was used to assess overall differences between groups. Results: The median serum CRP values for cases and controls were 64 ng/ml (interquartile range: 27 to 234 ng/ml) and 55 ng/ml (31 to 183 ng/ml), respectively (P = 0.8). Conclusions: Serum levels of CRP were not significantly higher among subjects with periodontitis than among controls. However, a statistically significant positive association between percentages of sites with bleeding on probing and log-transformed CRP values was observed.
Original languageEnglish
JournalJournal of Periodontology
Volume82
Issue number4
Pages (from-to)543-9
Number of pages7
ISSN0022-3492
DOIs
Publication statusPublished - 1 Apr 2011

ID: 32254937