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Rigshospitalet - a part of Copenhagen University Hospital
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Serum concentrations of mast cell tryptase are reduced in heavy drinkers

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Alcohol intake in early pregnancy and spontaneous preterm birth: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Carmen Beceiro
  • Joaquín Campos
  • Maria-Angeles Valcarcel
  • Runa V Fenger
  • Santiago Lojo
  • Allan Linneberg
  • Carmen Vidal
  • Arturo Gonzalez-Quintela
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BACKGROUND: Baseline serum tryptase concentrations are commonly used in clinical practice as a marker of the body's mast cell burden. This study aimed to investigate serum tryptase concentrations in heavy drinkers.

METHODS: Serum tryptase concentrations were determined in 126 heavy drinkers (75% males, median age 47 years) who were admitted to the hospital because of alcohol withdrawal syndrome (n = 60), general symptoms with abnormalities on biochemical tests that indicated acute liver disease (n = 19), complications of advanced liver disease (n = 33), and miscellaneous reasons (n = 14). Results were compared with those of 70 healthy controls (66% males, median age 40 years).

RESULTS: Serum tryptase concentrations were lower in heavy drinkers than in healthy controls (median 2.23 μg/l vs. median 3.25 μg/l, p < 0.001). Ten heavy drinkers (7.9%) had undetectable (<1 μg/l) serum tryptase levels versus none of the healthy controls (p = 0.01). The association of low tryptase levels with heavy drinking was independent of age, gender, and smoking status. Among heavy drinkers, the lowest tryptase concentrations were observed in patients with alcohol withdrawal syndrome and patients with general symptoms with abnormalities on biochemical tests that indicated acute liver disease. Furthermore, serum tryptase concentrations were negatively correlated with markers of acute liver damage or alcohol consumption (serum aspartate aminotransferase and gamma-glutamyl transferase). Atopy (skin prick test positivity) was not associated with serum tryptase concentrations in heavy drinkers.

CONCLUSIONS: Serum concentrations of mast cell tryptase are lower in heavy drinkers than in healthy controls.

Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume39
Issue number4
Pages (from-to)672-8
Number of pages7
ISSN0145-6008
DOIs
Publication statusPublished - Apr 2015

ID: 45266698