Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity-Comparison with other anxiety-related temperamental dimensions

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Germline whole genome sequencing in pediatric oncology in Denmark-Practitioner perspectives

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exome data clouds the pathogenicity of genetic variants in Pulmonary Arterial Hypertension

    Research output: Contribution to journalReviewResearchpeer-review

  3. Dentinogenesis imperfecta type II- genotype and phenotype analyses in three Danish families

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Analyses of more than 60,000 exomes questions the role of numerous genes previously associated with dilated cardiomyopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Trajectory of aberrant reward processing in patients with bipolar disorder - A longitudinal fMRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. An fMRI-compatible system for targeted electrical stimulation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Psychedelic Resting-state Neuroimaging: A Review and Perspective on Balancing Replication and Novel Analyses

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

BACKGROUND: The short (s) allele of the 5-HTTLPR polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene SLC6A4 has previously been associated with anxiety-related personality dimensions. However, this relationship has not been confirmed in all studies and may be modified by environmental circumstances and/or psychiatric illness. This study examined whether the temperamental trait sensory processing sensitivity (SPS), characterized by increased responsivity to environmental stimuli, is related to 5-HTTLPR/rs25531 genotype.

METHODS: 5-HTTLPR and rs25531 genotypes, level of SPS, self-reported Revised NEO Personality Inventory (NEO-PI-R) and Temperament and Character Inventory (TCI) personality profiles, and symptoms of psychological distress (SCL-90R Global Severity Index) were determined for 405 healthy volunteers.

RESULTS: Sensory processing sensitivity was highly correlated with the anxiety-related dimensions of the NEO-PI-R and the TCI models of personality, Neuroticism, and Harm Avoidance, respectively. However, the level of SPS was not associated with the combined 5-HTTLPR and rs25531 s'/s' genotype. Neuroticism and Harm Avoidance were also not associated with 5-HTTLPR/rs25531 s'/s' genotype. Correcting for symptoms of psychological distress had no effect on the relationships between personality and genotype.

CONCLUSION: The level of SPS was not associated with serotonin transporter gene variation. Further, combined 5-HTTLPR and rs25531 genotype was not associated with other anxiety-related dimensions.

Original languageEnglish
Article numbere1352
JournalMolecular Genetics & Genomic Medicine
Volume8
Issue number8
Pages (from-to)e1352
ISSN2324-9269
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • Harm Avoidance, Neuroticism, personality, serotonin, temperament

ID: 60966403