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Rigshospitalet - a part of Copenhagen University Hospital

Secular changes in puberty

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  1. Dynamic Changes in LH/FSH Ratios in Infants with Normal Sex Development

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Oophorectomy and rate of dementia: a prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Environmental factors in declining human fertility

    Research output: Contribution to journalReviewResearchpeer-review

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Throughout the last century, several studies from the US and Europe have demonstrated a secular trend towards earlier pubertal onset, particularly in girls. The initial clinical sign of pubertal onset is breast gland development in girls and testicular enlargement over 3 mL combined with penile growth in boys. In girls, menarche is sometimes used as a late marker of puberty. The precise mechanism behind the onset of puberty and the secular trends of puberty remain to be elucidated. This article briefly describes the physiology of normal puberty and sexual maturation, historic and recent secular changes in age at pubertal onset in girls and boys as well as changes in the incidence of precocious puberty. The article also discusses the possible mechanisms explaining the recent advancement in the onset of puberty.

Original languageEnglish
Title of host publicationEncyclopedia of Endocrine Diseases
Number of pages9
Publication date1 Jan 2018
ISBN (Print)9780128121993
ISBN (Electronic)9780128122006
Publication statusPublished - 1 Jan 2018

    Research areas

  • Boys, Girls, Precocious puberty, Puberty, Secular trend, Tanner stage

ID: 59588421