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Rigshospitalet - a part of Copenhagen University Hospital

Secular changes in puberty

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  1. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

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  3. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

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Throughout the last century, several studies from the US and Europe have demonstrated a secular trend towards earlier pubertal onset, particularly in girls. The initial clinical sign of pubertal onset is breast gland development in girls and testicular enlargement over 3 mL combined with penile growth in boys. In girls, menarche is sometimes used as a late marker of puberty. The precise mechanism behind the onset of puberty and the secular trends of puberty remain to be elucidated. This article briefly describes the physiology of normal puberty and sexual maturation, historic and recent secular changes in age at pubertal onset in girls and boys as well as changes in the incidence of precocious puberty. The article also discusses the possible mechanisms explaining the recent advancement in the onset of puberty.

Original languageEnglish
Title of host publicationEncyclopedia of Endocrine Diseases
Number of pages9
Publication date1 Jan 2018
ISBN (Print)9780128121993
ISBN (Electronic)9780128122006
Publication statusPublished - 1 Jan 2018

    Research areas

  • Boys, Girls, Precocious puberty, Puberty, Secular trend, Tanner stage

ID: 59588421