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Rigshospitalet - a part of Copenhagen University Hospital
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Screening for Down's syndrome using an iso-risk curve based on maternal age and serum alpha-fetoprotein level

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  • A Tabor
  • S O Larsen
  • J Nielsen
  • J Nielsen
  • J Philip
  • B Pilgaard
  • P Videbech
  • B Nørgaard-Pedersen
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On the basis of the significantly different distributions of maternal serum alpha-fetoprotein (AFP) levels in 86 pregnancies associated with fetal Down's syndrome and in 2018 unaffected pregnancies, an iso-risk curve for Down's syndrome was constructed. An iso-risk curve shows, for women of all ages, which combinations of maternal age and level of maternal serum AFP result in the same risk of carrying a fetus with Down's syndrome. A 1:400 risk of Down's syndrome, corresponding to the risk of a 35-year-old woman, was chosen as the lowest risk indicating referral for amniocentesis. If all women, irrespective of their age, are offered amniocentesis, when their risk of carrying a Down's syndrome fetus is 1:400 or higher, 53% of the affected fetuses can be detected as compared with 28% of the affected fetuses diagnosed at present in women above 35 years of age.

Original languageEnglish
JournalBritish Journal of Obstetrics and Gynaecology
Volume94
Issue number7
Pages (from-to)636-42
Number of pages7
ISSN0306-5456
Publication statusPublished - Jul 1987

    Research areas

  • Adult, Down Syndrome/diagnosis, Female, Fetal Diseases/diagnosis, Humans, Maternal Age, Pregnancy, Pregnancy, High-Risk, Prenatal Diagnosis/methods, Risk, alpha-Fetoproteins/analysis

ID: 54944367