Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Is cesarean section a cause of affective disorders?-A national cohort study using sibling designs

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: A randomized placebo-controlled study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The influence of the anesthesia-to-stimulation time interval on seizure quality parameters in electroconvulsive therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Amygdala response to emotional faces in seasonal affective disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cytokines, brain-derived neurotrophic factor and C-reactive protein in bipolar I disorder - Results from a prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effect of insulin on natriuretic peptide gene expression in porcine heart

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of glucose on risk of dementia: Mendelian randomisation studies in 115,875 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The calcium binding protein S100B and brain derived neurotrophic factor (BDNF) are both biomarkers implicated in neuronal processes in the central nervous system and seem to be associated with affective disorders. Here we investigated both markers in a sample of monozygotic (MZ) twins with, at risk of and without affective disorders, aiming to evaluate whether these markers have a role as causal factors- or trait markers for affective disorders.

METHOD: We measured serum S100B and plasma BDNF levels in 204 monozygotic twins (MZ) with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk).

RESULTS: No significant group differences in S100B and BDNF levels were found between the three groups. Exploratory analysis revealed that higher S100B levels were correlated with lower cognitive performance.

LIMITATIONS: The cross-sectional design cannot elucidate the two neuronal biomarkers role as causal factors. We would have preferred a higher sample size in the high- and low-risk groups.

CONCLUSION: The present result did not support a role for S100B and BDNF as neither causal factors nor trait markers for affective disorders. Elevated S100B levels may associate with impaired cognition, but further studies are warranted.

Original languageEnglish
JournalJournal of Affective Disorders
Volume274
Pages (from-to)726-732
Number of pages7
ISSN0165-0327
DOIs
Publication statusPublished - 1 Sep 2020

ID: 60406925