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Rigshospitalet - a part of Copenhagen University Hospital
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RNA assemblages orchestrate complex cellular processes

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DOI

  1. Cytoplasmic mRNPs revisited: Singletons and condensates

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

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  1. Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cytoplasmic mRNPs revisited: Singletons and condensates

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  3. Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage

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Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed in the present review.

Original languageEnglish
JournalBioEssays
Volume38
Issue number7
Pages (from-to)674-81
Number of pages8
ISSN0265-9247
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Journal Article

ID: 49833124