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Rigshospitalet - a part of Copenhagen University Hospital
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Risk of Lifetime Psychiatric Morbidity in Adults With Atrial Septal Defect (from a Nation-Wide Cohort)

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  • Camilla Nyboe
  • Sebastian Udholm
  • Signe Holm Larsen
  • Charlotte Ulrikka Rask
  • Andrew Redington
  • Vibeke Hjortdal
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In this nation-wide cohort study we report the first long-term results of the association between having a atrial septal defects (ASD) on psychiatric disorders and use of psychotropic agents. Through population-based registries we included Danish individuals born before 1994 who received an ASD diagnosis between 1959and 2013. We used Cox proportional hazards regression and Fine and Grey competing risk regression to estimate the risk of receiving a psychiatric diagnosis and use of psychotropic medicine compared with a gender and age matched background population cohort. In 2,277 patients with a median follow-up from ASD diagnosis of 23.4 years (range 0.2 to 59.3 years) we found ASD patients to have a higher risk of psychiatric disorders (adjusted hazard ratio [HR]: 3.9; 95% confidence interval [CI] 3.4 to 4.5) compared with the comparison cohort and a cumulative incidence of using psychotropic agents 30 years after the ASD diagnosis of 47.4% (95% CI: 40.3 to 55.1) in the ASD patients and 25.5%, (95% CI: 23.5 to 27.8) in the comparison cohort. Diagnosis of the ASD before the age of 15 years (adjusted HR: 3.4; 95% confidence interval: 2.0 to 4.0) and surgical correction of the defect (HR: 1.5 (95% CI: 1.2 to 1.8), p <0.0001) had a higher risk than those with an ASD diagnosis after the age of 15 years and those with transcatheter closure of the defect. In conclusion, ASD patients had increased long-term risk of psychiatric disorder and use of psychotropic agents compared with a gender and age matched general population controls.

Original languageEnglish
JournalThe American journal of cardiology
Volume128
Pages (from-to)1-6
Number of pages6
ISSN0002-9149
DOIs
Publication statusPublished - 1 Aug 2020

    Research areas

  • Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Cardiac Catheterization, Cardiac Surgical Procedures, Child, Child, Preschool, Denmark/epidemiology, Female, Heart Septal Defects, Atrial/diagnosis, Humans, Incidence, Infant, Male, Mental Disorders/drug therapy, Middle Aged, Proportional Hazards Models, Psychotropic Drugs/therapeutic use, Risk, Young Adult

ID: 62066047