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Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions

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Jansson, MRN, von Heymann-Horan, A, Rasmussen, BK, Albieri, V, Frederiksen, K, Suppli, N, Dalton, SO, Johansen, C & Bidstrup, PE 2018, 'Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions' Psycho-Oncology, vol. 27, no. 8, pp. 1930-36. https://doi.org/10.1002/pon.4744

APA

Jansson, M. R. N., von Heymann-Horan, A., Rasmussen, B. K., Albieri, V., Frederiksen, K., Suppli, N., ... Bidstrup, P. E. (2018). Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions. Psycho-Oncology, 27(8), 1930-36. https://doi.org/10.1002/pon.4744

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Author

Jansson, Maria R N ; von Heymann-Horan, Annika ; Rasmussen, Birthe K ; Albieri, Vanna ; Frederiksen, Kirsten ; Suppli, Nis ; Dalton, Susanne O ; Johansen, Christoffer ; Bidstrup, Pernille E. / Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions. In: Psycho-Oncology. 2018 ; Vol. 27, No. 8. pp. 1930-36.

Bibtex

@article{5686d08efa5443b097445731ad5469bb,
title = "Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions",
abstract = "OBJECTIVE: Suffering from malignant brain tumor is a stressful condition, for patients and their partners. In a retrospective cohort study using nationwide registries, we examined partners' risk for first use of antidepressants, anxiolytics, or hypnotics.METHODS: We followed all 4373 partners of adults with glioma, diagnosed in 1998 to 2013 in Denmark and a cohort of 43 808 partners of glioma-free persons matched 1:10. In Cox proportional hazard models, we estimated hazard ratios (HRs) for a first prescription of psychotropic medications (antidepressants, anxiolytics, or hypnotics) according to the partner's glioma status. Among partners of glioma patients, we further estimated HRs for a first prescription of psychotropic medication according to disease characteristics, sociodemographic factors, and bereavement.RESULTS: Two years after diagnosis, 29{\%} of female and 21{\%} of male partners of glioma patients had had a first prescription of psychotropic medication compared with 10{\%} in female and 8{\%} in male partners of glioma-free persons. Partners of glioma patients had a significantly increased, 4-fold higher risk for a first prescription of psychotropic medications in the first year after diagnosis than partners of glioma-free persons (HR 4.10, 95{\%} CI, 3.80:4.43). Among partners of glioma patients, the risk was significantly reduced in bereaved compared with non-bereaved partners.CONCLUSIONS: We have documented, for the first time, that the psychological impact of a diagnosis of glioma is such a severe stress exposure that it increases the risk for having medication prescribed to treat symptoms of anxiety, sleep problems, and depression.",
author = "Jansson, {Maria R N} and {von Heymann-Horan}, Annika and Rasmussen, {Birthe K} and Vanna Albieri and Kirsten Frederiksen and Nis Suppli and Dalton, {Susanne O} and Christoffer Johansen and Bidstrup, {Pernille E}",
note = "Copyright {\circledC} 2018 John Wiley & Sons, Ltd.",
year = "2018",
doi = "10.1002/pon.4744",
language = "English",
volume = "27",
pages = "1930--36",
journal = "Psycho-Oncology",
issn = "1057-9249",
publisher = "John/Wiley & Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients-A nationwide study covering 19 years of prescriptions

AU - Jansson, Maria R N

AU - von Heymann-Horan, Annika

AU - Rasmussen, Birthe K

AU - Albieri, Vanna

AU - Frederiksen, Kirsten

AU - Suppli, Nis

AU - Dalton, Susanne O

AU - Johansen, Christoffer

AU - Bidstrup, Pernille E

N1 - Copyright © 2018 John Wiley & Sons, Ltd.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: Suffering from malignant brain tumor is a stressful condition, for patients and their partners. In a retrospective cohort study using nationwide registries, we examined partners' risk for first use of antidepressants, anxiolytics, or hypnotics.METHODS: We followed all 4373 partners of adults with glioma, diagnosed in 1998 to 2013 in Denmark and a cohort of 43 808 partners of glioma-free persons matched 1:10. In Cox proportional hazard models, we estimated hazard ratios (HRs) for a first prescription of psychotropic medications (antidepressants, anxiolytics, or hypnotics) according to the partner's glioma status. Among partners of glioma patients, we further estimated HRs for a first prescription of psychotropic medication according to disease characteristics, sociodemographic factors, and bereavement.RESULTS: Two years after diagnosis, 29% of female and 21% of male partners of glioma patients had had a first prescription of psychotropic medication compared with 10% in female and 8% in male partners of glioma-free persons. Partners of glioma patients had a significantly increased, 4-fold higher risk for a first prescription of psychotropic medications in the first year after diagnosis than partners of glioma-free persons (HR 4.10, 95% CI, 3.80:4.43). Among partners of glioma patients, the risk was significantly reduced in bereaved compared with non-bereaved partners.CONCLUSIONS: We have documented, for the first time, that the psychological impact of a diagnosis of glioma is such a severe stress exposure that it increases the risk for having medication prescribed to treat symptoms of anxiety, sleep problems, and depression.

AB - OBJECTIVE: Suffering from malignant brain tumor is a stressful condition, for patients and their partners. In a retrospective cohort study using nationwide registries, we examined partners' risk for first use of antidepressants, anxiolytics, or hypnotics.METHODS: We followed all 4373 partners of adults with glioma, diagnosed in 1998 to 2013 in Denmark and a cohort of 43 808 partners of glioma-free persons matched 1:10. In Cox proportional hazard models, we estimated hazard ratios (HRs) for a first prescription of psychotropic medications (antidepressants, anxiolytics, or hypnotics) according to the partner's glioma status. Among partners of glioma patients, we further estimated HRs for a first prescription of psychotropic medication according to disease characteristics, sociodemographic factors, and bereavement.RESULTS: Two years after diagnosis, 29% of female and 21% of male partners of glioma patients had had a first prescription of psychotropic medication compared with 10% in female and 8% in male partners of glioma-free persons. Partners of glioma patients had a significantly increased, 4-fold higher risk for a first prescription of psychotropic medications in the first year after diagnosis than partners of glioma-free persons (HR 4.10, 95% CI, 3.80:4.43). Among partners of glioma patients, the risk was significantly reduced in bereaved compared with non-bereaved partners.CONCLUSIONS: We have documented, for the first time, that the psychological impact of a diagnosis of glioma is such a severe stress exposure that it increases the risk for having medication prescribed to treat symptoms of anxiety, sleep problems, and depression.

U2 - 10.1002/pon.4744

DO - 10.1002/pon.4744

M3 - Journal article

VL - 27

SP - 1930

EP - 1936

JO - Psycho-Oncology

JF - Psycho-Oncology

SN - 1057-9249

IS - 8

ER -

ID: 54658690