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Risk factors for infections in newly diagnosed Multiple Myeloma patients: A Danish retrospective nationwide cohort study

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@article{253f46ea3c8c4417ad166057d6f91cae,
title = "Risk factors for infections in newly diagnosed Multiple Myeloma patients: A Danish retrospective nationwide cohort study",
abstract = "OBJECTIVES: Infections pose the greatest risk of early death in patients with Multiple Myeloma. However, few studies have analyzed the risk factors for infections in Multiple Myeloma patients. The aim of this study was to analyze the risk factors infections within a population-based MM cohort.METHODS: Using Danish registries (from 2005 to 2013), we analyzed all ICD-10 codes for infections within the first 6 months of Multiple Myeloma diagnosis in 2557 patients.RESULTS: Pneumonia and sepsis represented 46% of infections. Multivariable regression analysis showed that risk factors for pneumonia were male gender (HR 1.4; P = 0.001), ISS II (HR 1.6; P = 0.0004) and ISSIII (HR 1.8; P = 0.0004) and elevated LDH (HR 2.6; P = 0.0008). Risk factors for sepsis were high bone marrow plasma cell % (HR 1.1; P = 0.038), ISS II (HR 1.7; P = 0.007) ISS III (HR 2.0; P = 0.002) and creatinine (HR 2.1; P = 0.002). Neither immunoparesis (hypogammaglobulinemia) nor comorbidity was significant risk factors.CONCLUSIONS: Our study suggests that tumor burden and renal impairment are risk factors for pneumonia and sepsis in the early phase of Multiple Myeloma.",
keywords = "immunoparesis, infection, multiple myeloma, risk factors, Multiple Myeloma/complications, Infections/diagnosis, Prognosis, Comorbidity, Humans, Middle Aged, Risk Factors, Male, Incidence, Denmark/epidemiology, Time Factors, Aged, 80 and over, Biomarkers, Adult, Female, Registries, Aged, Retrospective Studies, Population Surveillance",
author = "Rasmus S{\o}rrig and Klausen, {Tobias W} and Morten Salomo and Annette Vangsted and Peter Gimsing",
note = "{\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2019",
month = feb,
day = "1",
doi = "10.1111/ejh.13190",
language = "English",
volume = "102",
pages = "182--190",
journal = "European Journal of Haematology",
issn = "0902-4441",
publisher = "Wiley-Blackwell Munksgaard",
number = "2",

}

RIS

TY - JOUR

T1 - Risk factors for infections in newly diagnosed Multiple Myeloma patients

T2 - A Danish retrospective nationwide cohort study

AU - Sørrig, Rasmus

AU - Klausen, Tobias W

AU - Salomo, Morten

AU - Vangsted, Annette

AU - Gimsing, Peter

N1 - © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - OBJECTIVES: Infections pose the greatest risk of early death in patients with Multiple Myeloma. However, few studies have analyzed the risk factors for infections in Multiple Myeloma patients. The aim of this study was to analyze the risk factors infections within a population-based MM cohort.METHODS: Using Danish registries (from 2005 to 2013), we analyzed all ICD-10 codes for infections within the first 6 months of Multiple Myeloma diagnosis in 2557 patients.RESULTS: Pneumonia and sepsis represented 46% of infections. Multivariable regression analysis showed that risk factors for pneumonia were male gender (HR 1.4; P = 0.001), ISS II (HR 1.6; P = 0.0004) and ISSIII (HR 1.8; P = 0.0004) and elevated LDH (HR 2.6; P = 0.0008). Risk factors for sepsis were high bone marrow plasma cell % (HR 1.1; P = 0.038), ISS II (HR 1.7; P = 0.007) ISS III (HR 2.0; P = 0.002) and creatinine (HR 2.1; P = 0.002). Neither immunoparesis (hypogammaglobulinemia) nor comorbidity was significant risk factors.CONCLUSIONS: Our study suggests that tumor burden and renal impairment are risk factors for pneumonia and sepsis in the early phase of Multiple Myeloma.

AB - OBJECTIVES: Infections pose the greatest risk of early death in patients with Multiple Myeloma. However, few studies have analyzed the risk factors for infections in Multiple Myeloma patients. The aim of this study was to analyze the risk factors infections within a population-based MM cohort.METHODS: Using Danish registries (from 2005 to 2013), we analyzed all ICD-10 codes for infections within the first 6 months of Multiple Myeloma diagnosis in 2557 patients.RESULTS: Pneumonia and sepsis represented 46% of infections. Multivariable regression analysis showed that risk factors for pneumonia were male gender (HR 1.4; P = 0.001), ISS II (HR 1.6; P = 0.0004) and ISSIII (HR 1.8; P = 0.0004) and elevated LDH (HR 2.6; P = 0.0008). Risk factors for sepsis were high bone marrow plasma cell % (HR 1.1; P = 0.038), ISS II (HR 1.7; P = 0.007) ISS III (HR 2.0; P = 0.002) and creatinine (HR 2.1; P = 0.002). Neither immunoparesis (hypogammaglobulinemia) nor comorbidity was significant risk factors.CONCLUSIONS: Our study suggests that tumor burden and renal impairment are risk factors for pneumonia and sepsis in the early phase of Multiple Myeloma.

KW - immunoparesis

KW - infection

KW - multiple myeloma

KW - risk factors

KW - Multiple Myeloma/complications

KW - Infections/diagnosis

KW - Prognosis

KW - Comorbidity

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Incidence

KW - Denmark/epidemiology

KW - Time Factors

KW - Aged, 80 and over

KW - Biomarkers

KW - Adult

KW - Female

KW - Registries

KW - Aged

KW - Retrospective Studies

KW - Population Surveillance

U2 - 10.1111/ejh.13190

DO - 10.1111/ejh.13190

M3 - Journal article

C2 - 30485563

VL - 102

SP - 182

EP - 190

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 2

ER -

ID: 55863472