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Rigshospitalet - a part of Copenhagen University Hospital
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Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS)

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  1. Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Age-related changes in human Leydig cell status

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  2. Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

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  3. High serum FSH is not a risk factor for low bone mineral density in infertile men

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  4. Evaluation of Serum Insulin-like Factor 3 Quantification by LC-MS/MS as a Biomarker of Leydig Cell Function

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  5. Psychological stress, stressful life events, male factor infertility, and testicular function: a cross-sectional study

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Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24⁻26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells.

Original languageEnglish
JournalInternational Journal of Environmental Research and Public Health
Volume15
Issue number9
Pages (from-to)E1880
ISSN1661-7827
DOIs
Publication statusPublished - 30 Aug 2018

ID: 56304226