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Rigshospitalet - a part of Copenhagen University Hospital
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Reproductive endocrinology of vitamin D

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  1. Progressive changes in human follicular fluid composition over the course of ovulation: quantitative proteomic analyses

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  2. Human granulosa cells function as innate immune cells executing an inflammatory reaction during ovulation: a microarray analysis

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  3. Identification of circulating small non-coding RNAs in relation to male subfertility and reproductive hormones

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  4. Experimental models of testicular development and function using human tissue and cells

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  1. Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

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  2. Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment

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  3. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

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  4. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

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  5. The External Genitalia Score (EGS): A European multicenter validation study

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Vitamin D is a versatile hormone with several functions beyond its well-established role in maintenance of skeletal health and calcium homeostasis. The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues. The reproductive organs are therefore responsive to and able to metabolize vitamin D locally. The exact role remains to be clarified but several studies have suggested a link between vitamin D and production/release of reproductive hormones into circulation, which will be the main focus of this review. Current evidence is primarily based on small human association studies and rodent models. This highlights the need for randomized clinical trials, but also functional animal and human in vitro studies, and larger, prospective cohort studies are warranted. Given the high number of men and women suffering from reproductive problems and abnormal endocrinology research addressing the role of vitamin D in reproductive endocrinology is of clinical importance.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume453
Pages (from-to)103-112
ISSN0303-7207
DOIs
Publication statusPublished - 15 Sep 2017

    Research areas

  • Journal Article

ID: 50151076