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Rigshospitalet - a part of Copenhagen University Hospital
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Relationship between patient presentation and morphology of coronary atherosclerosis by quantitative multidetector computed tomography

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  • Martina C de Knegt
  • Jesper J Linde
  • Andreas Fuchs
  • Michael H C Pham
  • Andreas K Jensen
  • Børge G Nordestgaard
  • Henning Kelbæk
  • Lars V Køber
  • Merete Heitmann
  • Gitte Fornitz
  • Jens D Hove
  • Klaus F Kofoed
  • CGPS, the CATCH, and the VERDICT Investigators
  • Rolf Steffensen (Member of study group)
  • Birgit Jurlander (Member of study group)
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AIMS: Quantitative computed tomography (QCT) allows assessment of morphological features of coronary atherosclerosis. We aimed to test the hypothesis that clinical patient presentation is associated with distinct morphological features of coronary atherosclerosis.

METHODS AND RESULTS: A total of 1652 participants, representing a spectrum of clinical risk profiles [787 asymptomatic individuals from the general population, 468 patients with acute chest pain without acute coronary syndrome (ACS), and 397 patients with acute chest pain and ACS], underwent multidetector computed tomography. Of these, 274 asymptomatic individuals, 254 patients with acute chest pain without ACS, and 327 patients with acute chest pain and ACS underwent QCT to assess coronary plaque volumes and proportions of dense calcium (DC), fibrous, fibro fatty (FF), and necrotic core (NC) tissue. Furthermore, the presence of vulnerable plaques, defined by plaque volume and tissue composition, was examined. Coronary plaque volume increased significantly with worsening clinical risk profile [geometric mean (95% confidence interval): 148 (129-166) mm3, 257 (224-295) mm3, and 407 (363-457) mm3, respectively, P < 0.001]. Plaque composition differed significantly across cohorts, P < 0.0001. The proportion of DC decreased, whereas FF and NC increased with worsening clinical risk profile (mean proportions DC: 33%, 23%, 23%; FF: 50%, 61%, 57%; and NC: 17%, 17%, 20%, respectively). Significant differences in plaque composition persisted after multivariable adjustment for age, gender, body surface area, hypertension, statin use at baseline, diabetes, smoking, family history of ischaemic heart disease, total plaque volume, and tube voltage, P < 0.01.

CONCLUSION: Coronary atherosclerotic plaque volume and composition are strongly associated to clinical presentation.

Original languageEnglish
JournalEuropean heart journal cardiovascular Imaging
Volume20
Issue number11
Pages (from-to)1221-1230
Number of pages10
ISSN1525-2167
DOIs
Publication statusPublished - 1 Nov 2019

    Research areas

  • atherosclerosis, cardiac computed tomography angiography, plaque composition, plaque quantification, plaque volume, quantitative computed tomography

ID: 58247918